Human health risk assessment for peroxisome proliferators: More than 30 years of research

Marco Fidaleo

Research output: Contribution to journalArticle

Abstract

Substances like gemfibrozil, clofibrate and fenofibrate, widely used in human care for their hypolipidemic effects, belong to a larger class of chemicals called peroxisome proliferators (PPs). PPs, by binding and activing the peroxisome proliferator-activated receptor α (PPARα), modulate gene involved in lipid homeostasis both in human and in rodent. In a different way, long term administration of PPs results in hepatocarcinogenesis only in rodent. Although the phenomenon is known since more than 30 years, the exact mechanism is not well understood and the human health risks are not established. In this mini-review is inspected the major findings done in the different species and illustrates the possible doubts for human health by the use of PPs.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalExperimental and Toxicologic Pathology
Volume61
Issue number3
DOIs
Publication statusPublished - May 2009

Keywords

  • Apoptosis
  • Cell proliferation
  • Hepatocarcinogenesis
  • Oxidative stress
  • Peroxisome proliferator (PP)
  • Peroxisome proliferator-activated receptor α (PPARα)

ASJC Scopus subject areas

  • Cell Biology
  • Pathology and Forensic Medicine
  • Toxicology

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