Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men

V. Ascoli, C. Carnovale Scalzo, C. Danese, K. Vacca, A. Pistilli, F. Lo Coco

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Human herpes virus-8 (HHV-8)-associated primary effusion lymphoma (PEL) is an unusual lymphoma confined to the body cavities, which primarily affects human immunodeficiency virus (HV)-positive men at high risk for Kaposi's sarcoma (KS). We describe two HIV-negative elderly Italian men, who developed pleural HHV-8-positive PEL in association with other diseases (systemic hypertension, colonic carcinoma, chronic obstructive airways disease, dilated cardiomyopathy), but without KS. Thoracic computed tomography revealed unilateral pleural effusion and pleural thickening. Thoracentesis disclosed large lymphoma cells, with no T- or B-cell associated antigens, clonal rearrangement of the immunoglobulin heavy chain gene and the presence of HHV- 8 but not Epstein-Barr virus deoxyribonucleic acid sequences. Our cases differ from most pleural effusion lymphomas, in that they are nonacquired immunodeficiency syndrome-related. This highlights the possible human herpes virus-8-associated primary effusion lymphoma risk among elderly human immunodeficiency virus-negative patients, particularly Italians, in whom human herpes virus-8 seroprevalence rates and incidence of classic Kaposi's sarcoma are high.

Original languageEnglish
Pages (from-to)1231-1234
Number of pages4
JournalEuropean Respiratory Journal
Volume14
Issue number5
Publication statusPublished - 1999

Fingerprint

Primary Effusion Lymphoma
Pleural Cavity
Kaposi's Sarcoma
HIV
Viruses
Lymphoma
Pleural Effusion
Immunoglobulin Heavy Chain Genes
Human Herpesvirus 8
Seroepidemiologic Studies
Dilated Cardiomyopathy
Human Herpesvirus 4
Chronic Obstructive Pulmonary Disease
B-Lymphocytes
Thorax
Tomography
Hypertension
Carcinoma
Antigens
DNA

Keywords

  • Ageing
  • Human herpes virus-8
  • Italy
  • Kaposi's sarcoma
  • Pleural cavity
  • Primary effusion lymphoma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ascoli, V., Carnovale Scalzo, C., Danese, C., Vacca, K., Pistilli, A., & Lo Coco, F. (1999). Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men. European Respiratory Journal, 14(5), 1231-1234.

Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men. / Ascoli, V.; Carnovale Scalzo, C.; Danese, C.; Vacca, K.; Pistilli, A.; Lo Coco, F.

In: European Respiratory Journal, Vol. 14, No. 5, 1999, p. 1231-1234.

Research output: Contribution to journalArticle

Ascoli, V, Carnovale Scalzo, C, Danese, C, Vacca, K, Pistilli, A & Lo Coco, F 1999, 'Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men', European Respiratory Journal, vol. 14, no. 5, pp. 1231-1234.
Ascoli, V. ; Carnovale Scalzo, C. ; Danese, C. ; Vacca, K. ; Pistilli, A. ; Lo Coco, F. / Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men. In: European Respiratory Journal. 1999 ; Vol. 14, No. 5. pp. 1231-1234.
@article{102c610e8d254d909dc0c7fe406fdf79,
title = "Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men",
abstract = "Human herpes virus-8 (HHV-8)-associated primary effusion lymphoma (PEL) is an unusual lymphoma confined to the body cavities, which primarily affects human immunodeficiency virus (HV)-positive men at high risk for Kaposi's sarcoma (KS). We describe two HIV-negative elderly Italian men, who developed pleural HHV-8-positive PEL in association with other diseases (systemic hypertension, colonic carcinoma, chronic obstructive airways disease, dilated cardiomyopathy), but without KS. Thoracic computed tomography revealed unilateral pleural effusion and pleural thickening. Thoracentesis disclosed large lymphoma cells, with no T- or B-cell associated antigens, clonal rearrangement of the immunoglobulin heavy chain gene and the presence of HHV- 8 but not Epstein-Barr virus deoxyribonucleic acid sequences. Our cases differ from most pleural effusion lymphomas, in that they are nonacquired immunodeficiency syndrome-related. This highlights the possible human herpes virus-8-associated primary effusion lymphoma risk among elderly human immunodeficiency virus-negative patients, particularly Italians, in whom human herpes virus-8 seroprevalence rates and incidence of classic Kaposi's sarcoma are high.",
keywords = "Ageing, Human herpes virus-8, Italy, Kaposi's sarcoma, Pleural cavity, Primary effusion lymphoma",
author = "V. Ascoli and {Carnovale Scalzo}, C. and C. Danese and K. Vacca and A. Pistilli and {Lo Coco}, F.",
year = "1999",
language = "English",
volume = "14",
pages = "1231--1234",
journal = "European Journal of Respiratory Diseases",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "5",

}

TY - JOUR

T1 - Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men

AU - Ascoli, V.

AU - Carnovale Scalzo, C.

AU - Danese, C.

AU - Vacca, K.

AU - Pistilli, A.

AU - Lo Coco, F.

PY - 1999

Y1 - 1999

N2 - Human herpes virus-8 (HHV-8)-associated primary effusion lymphoma (PEL) is an unusual lymphoma confined to the body cavities, which primarily affects human immunodeficiency virus (HV)-positive men at high risk for Kaposi's sarcoma (KS). We describe two HIV-negative elderly Italian men, who developed pleural HHV-8-positive PEL in association with other diseases (systemic hypertension, colonic carcinoma, chronic obstructive airways disease, dilated cardiomyopathy), but without KS. Thoracic computed tomography revealed unilateral pleural effusion and pleural thickening. Thoracentesis disclosed large lymphoma cells, with no T- or B-cell associated antigens, clonal rearrangement of the immunoglobulin heavy chain gene and the presence of HHV- 8 but not Epstein-Barr virus deoxyribonucleic acid sequences. Our cases differ from most pleural effusion lymphomas, in that they are nonacquired immunodeficiency syndrome-related. This highlights the possible human herpes virus-8-associated primary effusion lymphoma risk among elderly human immunodeficiency virus-negative patients, particularly Italians, in whom human herpes virus-8 seroprevalence rates and incidence of classic Kaposi's sarcoma are high.

AB - Human herpes virus-8 (HHV-8)-associated primary effusion lymphoma (PEL) is an unusual lymphoma confined to the body cavities, which primarily affects human immunodeficiency virus (HV)-positive men at high risk for Kaposi's sarcoma (KS). We describe two HIV-negative elderly Italian men, who developed pleural HHV-8-positive PEL in association with other diseases (systemic hypertension, colonic carcinoma, chronic obstructive airways disease, dilated cardiomyopathy), but without KS. Thoracic computed tomography revealed unilateral pleural effusion and pleural thickening. Thoracentesis disclosed large lymphoma cells, with no T- or B-cell associated antigens, clonal rearrangement of the immunoglobulin heavy chain gene and the presence of HHV- 8 but not Epstein-Barr virus deoxyribonucleic acid sequences. Our cases differ from most pleural effusion lymphomas, in that they are nonacquired immunodeficiency syndrome-related. This highlights the possible human herpes virus-8-associated primary effusion lymphoma risk among elderly human immunodeficiency virus-negative patients, particularly Italians, in whom human herpes virus-8 seroprevalence rates and incidence of classic Kaposi's sarcoma are high.

KW - Ageing

KW - Human herpes virus-8

KW - Italy

KW - Kaposi's sarcoma

KW - Pleural cavity

KW - Primary effusion lymphoma

UR - http://www.scopus.com/inward/record.url?scp=0344241153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344241153&partnerID=8YFLogxK

M3 - Article

C2 - 10596717

AN - SCOPUS:0344241153

VL - 14

SP - 1231

EP - 1234

JO - European Journal of Respiratory Diseases

JF - European Journal of Respiratory Diseases

SN - 0903-1936

IS - 5

ER -