Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men

V. Ascoli, C. Carnovale Scalzo, C. Danese, K. Vacca, A. Pistilli, F. Lo Coco

Research output: Contribution to journalArticle

Abstract

Human herpes virus-8 (HHV-8)-associated primary effusion lymphoma (PEL) is an unusual lymphoma confined to the body cavities, which primarily affects human immunodeficiency virus (HV)-positive men at high risk for Kaposi's sarcoma (KS). We describe two HIV-negative elderly Italian men, who developed pleural HHV-8-positive PEL in association with other diseases (systemic hypertension, colonic carcinoma, chronic obstructive airways disease, dilated cardiomyopathy), but without KS. Thoracic computed tomography revealed unilateral pleural effusion and pleural thickening. Thoracentesis disclosed large lymphoma cells, with no T- or B-cell associated antigens, clonal rearrangement of the immunoglobulin heavy chain gene and the presence of HHV- 8 but not Epstein-Barr virus deoxyribonucleic acid sequences. Our cases differ from most pleural effusion lymphomas, in that they are nonacquired immunodeficiency syndrome-related. This highlights the possible human herpes virus-8-associated primary effusion lymphoma risk among elderly human immunodeficiency virus-negative patients, particularly Italians, in whom human herpes virus-8 seroprevalence rates and incidence of classic Kaposi's sarcoma are high.

Original languageEnglish
Pages (from-to)1231-1234
Number of pages4
JournalEuropean Respiratory Journal
Volume14
Issue number5
Publication statusPublished - 1999

Keywords

  • Ageing
  • Human herpes virus-8
  • Italy
  • Kaposi's sarcoma
  • Pleural cavity
  • Primary effusion lymphoma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Ascoli, V., Carnovale Scalzo, C., Danese, C., Vacca, K., Pistilli, A., & Lo Coco, F. (1999). Human herpes virus-8 associated primary effusion lymphoma of the pleural cavity in HIV-negative elderly men. European Respiratory Journal, 14(5), 1231-1234.