Abstract
Background and objectives Since HHV-6 reactivation after transplant has been reported to increase the risk of CMV infection, we tested this hypothesis in the HLA-haploidentical hematopoietic stem cell transplantation setting. Study design From February 2011 to October 2015, 75 patients received hematopoietic stem cell transplantation using a T-cell replete graft from a HLA-haploidentical donor at our Institution. Results Interestingly, 87% of HHV-6 reactivations were followed by a CMV reactivation, at a median of 15 days between the two viruses. Incidence of CMV reactivation was 14.5-fold higher in those patients with prior HHV-6 reactivation vs. those without it (p-value < 0.001). Conclusion The present results suggest that HHV-6 can be considered as a predicting indicator of cellular immunosuppression preceding the onset of CMV infection.
Original language | English |
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Pages (from-to) | 24-26 |
Number of pages | 3 |
Journal | Journal of Clinical Virology |
Volume | 84 |
DOIs | |
Publication status | Published - Nov 1 2016 |
Keywords
- CMV
- Haploidentical HSCT
- HHV-6
- T-cell replete
- Viral replication
ASJC Scopus subject areas
- Infectious Diseases
- Virology