Human Herpesvirus 6 replication predicts Cytomegalovirus reactivation after allogeneic stem cell transplantation from haploidentical donor

Research output: Contribution to journalArticle

Abstract

Background and objectives Since HHV-6 reactivation after transplant has been reported to increase the risk of CMV infection, we tested this hypothesis in the HLA-haploidentical hematopoietic stem cell transplantation setting. Study design From February 2011 to October 2015, 75 patients received hematopoietic stem cell transplantation using a T-cell replete graft from a HLA-haploidentical donor at our Institution. Results Interestingly, 87% of HHV-6 reactivations were followed by a CMV reactivation, at a median of 15 days between the two viruses. Incidence of CMV reactivation was 14.5-fold higher in those patients with prior HHV-6 reactivation vs. those without it (p-value < 0.001). Conclusion The present results suggest that HHV-6 can be considered as a predicting indicator of cellular immunosuppression preceding the onset of CMV infection.

Original languageEnglish
Pages (from-to)24-26
Number of pages3
JournalJournal of Clinical Virology
Volume84
DOIs
Publication statusPublished - Nov 1 2016

Keywords

  • CMV
  • Haploidentical HSCT
  • HHV-6
  • T-cell replete
  • Viral replication

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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