Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS

B. Bigoni, R. Dolcetti, L. De Lellis, A. Carbone, M. Boiocchi, E. Cassai, D. Di Luca

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Abstract

In this study the prevalence of human herpesvirus (HHV) 8 DNA was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-seronegative and HIV-infected persons. The results show that HHV-8 is present in ~10% of biopsies from HIV-seronegative persons; HHV-8 is detected with similar prevalence values in HIV-infected patients with lymphoproliferative diseases, but the virus load is higher. HHV-8 was also found in PBMC. The presence of monoclonal Epstein-Barr virus (EBV) genomes in malignant lymphoproliferations was only infrequently associated with HHV-8 infection. Therefore, HHV-8 is fairly common in the population, and the lymphoid system could represent a reservoir of latently infected cells from which the virus may reactivate in conditions of immunodepression; furthermore, HHV-8 and EBV do not seem to act in conjunction in lymphomagenesis.

Original languageEnglish
Pages (from-to)542-549
Number of pages8
JournalJournal of Infectious Diseases
Volume173
Issue number3
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Bigoni, B., Dolcetti, R., De Lellis, L., Carbone, A., Boiocchi, M., Cassai, E., & Di Luca, D. (1996). Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS. Journal of Infectious Diseases, 173(3), 542-549.