Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS

B. Bigoni; R. Dolcetti; L. De Lellis; A. Carbone; M. Boiocchi; E. Cassai; D. Di Luca

Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS

B. Bigoni, R. Dolcetti, L. De Lellis, A. Carbone, M. Boiocchi, E. Cassai, D. Di Luca

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

In this study the prevalence of human herpesvirus (HHV) 8 DNA was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-seronegative and HIV-infected persons. The results show that HHV-8 is present in ~10% of biopsies from HIV-seronegative persons; HHV-8 is detected with similar prevalence values in HIV-infected patients with lymphoproliferative diseases, but the virus load is higher. HHV-8 was also found in PBMC. The presence of monoclonal Epstein-Barr virus (EBV) genomes in malignant lymphoproliferations was only infrequently associated with HHV-8 infection. Therefore, HHV-8 is fairly common in the population, and the lymphoid system could represent a reservoir of latently infected cells from which the virus may reactivate in conditions of immunodepression; furthermore, HHV-8 and EBV do not seem to act in conjunction in lymphomagenesis.

Original language	English
Pages (from-to)	542-549
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	173
Issue number	3
Publication status	Published - 1996

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Immunology

Fingerprint Dive into the research topics of 'Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS'. Together they form a unique fingerprint.

Cite this

@article{454f6bc9cd224a38bec13445183ba568,

title = "Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS",

abstract = "In this study the prevalence of human herpesvirus (HHV) 8 DNA was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-seronegative and HIV-infected persons. The results show that HHV-8 is present in ~10% of biopsies from HIV-seronegative persons; HHV-8 is detected with similar prevalence values in HIV-infected patients with lymphoproliferative diseases, but the virus load is higher. HHV-8 was also found in PBMC. The presence of monoclonal Epstein-Barr virus (EBV) genomes in malignant lymphoproliferations was only infrequently associated with HHV-8 infection. Therefore, HHV-8 is fairly common in the population, and the lymphoid system could represent a reservoir of latently infected cells from which the virus may reactivate in conditions of immunodepression; furthermore, HHV-8 and EBV do not seem to act in conjunction in lymphomagenesis.",

author = "B. Bigoni and R. Dolcetti and {De Lellis}, L. and A. Carbone and M. Boiocchi and E. Cassai and {Di Luca}, D.",

year = "1996",

language = "English",

volume = "173",

pages = "542--549",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Human herpesvirus 8 is present in the lymphoid system of healthy persons and can reactivate in the course of AIDS

AU - Bigoni, B.

AU - Dolcetti, R.

AU - De Lellis, L.

AU - Carbone, A.

AU - Boiocchi, M.

AU - Cassai, E.

AU - Di Luca, D.

PY - 1996

Y1 - 1996

N2 - In this study the prevalence of human herpesvirus (HHV) 8 DNA was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-seronegative and HIV-infected persons. The results show that HHV-8 is present in ~10% of biopsies from HIV-seronegative persons; HHV-8 is detected with similar prevalence values in HIV-infected patients with lymphoproliferative diseases, but the virus load is higher. HHV-8 was also found in PBMC. The presence of monoclonal Epstein-Barr virus (EBV) genomes in malignant lymphoproliferations was only infrequently associated with HHV-8 infection. Therefore, HHV-8 is fairly common in the population, and the lymphoid system could represent a reservoir of latently infected cells from which the virus may reactivate in conditions of immunodepression; furthermore, HHV-8 and EBV do not seem to act in conjunction in lymphomagenesis.

AB - In this study the prevalence of human herpesvirus (HHV) 8 DNA was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-seronegative and HIV-infected persons. The results show that HHV-8 is present in ~10% of biopsies from HIV-seronegative persons; HHV-8 is detected with similar prevalence values in HIV-infected patients with lymphoproliferative diseases, but the virus load is higher. HHV-8 was also found in PBMC. The presence of monoclonal Epstein-Barr virus (EBV) genomes in malignant lymphoproliferations was only infrequently associated with HHV-8 infection. Therefore, HHV-8 is fairly common in the population, and the lymphoid system could represent a reservoir of latently infected cells from which the virus may reactivate in conditions of immunodepression; furthermore, HHV-8 and EBV do not seem to act in conjunction in lymphomagenesis.

UR - http://www.scopus.com/inward/record.url?scp=0030040132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030040132&partnerID=8YFLogxK

M3 - Article

C2 - 8627015

AN - SCOPUS:0030040132

VL - 173

SP - 542

EP - 549

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -