Abstract
In this study the prevalence of human herpesvirus (HHV) 8 DNA was determined in biopsies from persons with lymphoproliferative disorders and in peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-seronegative and HIV-infected persons. The results show that HHV-8 is present in ~10% of biopsies from HIV-seronegative persons; HHV-8 is detected with similar prevalence values in HIV-infected patients with lymphoproliferative diseases, but the virus load is higher. HHV-8 was also found in PBMC. The presence of monoclonal Epstein-Barr virus (EBV) genomes in malignant lymphoproliferations was only infrequently associated with HHV-8 infection. Therefore, HHV-8 is fairly common in the population, and the lymphoid system could represent a reservoir of latently infected cells from which the virus may reactivate in conditions of immunodepression; furthermore, HHV-8 and EBV do not seem to act in conjunction in lymphomagenesis.
Original language | English |
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Pages (from-to) | 542-549 |
Number of pages | 8 |
Journal | Journal of Infectious Diseases |
Volume | 173 |
Issue number | 3 |
Publication status | Published - 1996 |
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology