TY - JOUR
T1 - Human Herpesvirus-8 Serology in Pediatric Organ Transplantation
AU - Concato, C.
AU - Diociaiuti, A.
AU - Parisi, F.
AU - Giraldi, L.
AU - Ciasulli, A.
AU - Menichella, D.
AU - El Hachem, M.
PY - 2008/12
Y1 - 2008/12
N2 - Human herpesvirus (HHV)-8 has been demonstrated to be involved in the pathogenesis of Kaposi's sarcoma, body cavity lymphomas, multicentric Castleman disease, and, more recently, acute bone marrow failure. In order to study the correlation between HHV-8 and immunosuppression, we performed a serological study in a group of 28 pediatric heart and heart-lung transplant recipients; of mean age 11.5 ± 2.5 years. We analyzed blood samples prior to, at 3 to 6 months, and at least 12 months after transplantation. All patients were negative pretransplantation. We observed 10 seroconversions: one patient at 6 months; two patients at 12 months; and seven within the third year after transplantation. Our preliminary data demonstrated that HHV-8 seroconversion is frequent among pediatric transplant recipients. It was probably related to the length of immunosuppression rather than the organ transplantation; Serological assays of all donor specimens of seroconverted patients were negative.
AB - Human herpesvirus (HHV)-8 has been demonstrated to be involved in the pathogenesis of Kaposi's sarcoma, body cavity lymphomas, multicentric Castleman disease, and, more recently, acute bone marrow failure. In order to study the correlation between HHV-8 and immunosuppression, we performed a serological study in a group of 28 pediatric heart and heart-lung transplant recipients; of mean age 11.5 ± 2.5 years. We analyzed blood samples prior to, at 3 to 6 months, and at least 12 months after transplantation. All patients were negative pretransplantation. We observed 10 seroconversions: one patient at 6 months; two patients at 12 months; and seven within the third year after transplantation. Our preliminary data demonstrated that HHV-8 seroconversion is frequent among pediatric transplant recipients. It was probably related to the length of immunosuppression rather than the organ transplantation; Serological assays of all donor specimens of seroconverted patients were negative.
UR - http://www.scopus.com/inward/record.url?scp=57549113129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57549113129&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2008.06.085
DO - 10.1016/j.transproceed.2008.06.085
M3 - Article
C2 - 19100465
AN - SCOPUS:57549113129
VL - 40
SP - 3683
EP - 3684
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 10
ER -