Human herpesvirus type 6 hepatitis or familiar intrahepatic cholestasis: The importance of follow-up

Valerio Nobili, Andrea Pietrobattista, Paola Francalanci, Ilaria Giovannoni, Matilde Marcellini, Sandro Vento

Research output: Contribution to journalArticlepeer-review

Abstract

A 1-month-old child presented to our unit with jaundice and raised aminotransferases, γ-glutamy ltranspeptidase and bilirubin. Metabolic diseases were ruled out and ultrasound found no alterations. Human herpesvirus type 6 (HHV-6) DNA was found in blood and saliva and IgG anti-HHV-6 in serum, and a diagnosis of HHV-6 hepatitis was made. In the following weeks, aminotransferase values remained raised while γ-glutamy ltranspeptidase levels returned to normal in 45 days. At the age of 5 months symptoms and elevated aminotransferases persisted and immunohistochemistry performed on liver tissue allowed a diagnosis of progressive familiar intrahepatic cholestasis type 2 to be made. The patient is now 7 months old, and cholestatic jaundice and pruritus continue to be present.

Original languageEnglish
JournalBMJ Case Reports
DOIs
Publication statusPublished - Feb 26 2009

ASJC Scopus subject areas

  • Medicine(all)

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