Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)

Roberta La Starza, Maurizio Trubia, Barbara Crescenzi, Caterina Matteucci, Massimo Negrini, Massimo F. Martelli, Pier Giuseppe Pelicci, Cristina Mecucci

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15; q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q 13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies.

Original languageEnglish
Pages (from-to)420-423
Number of pages4
JournalGenes Chromosomes and Cancer
Volume36
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

Fingerprint

Homeobox Genes
Acute Myeloid Leukemia
Genes
Multigene Family
Fluorescence In Situ Hybridization
Polymerase Chain Reaction
nuclear pore complex protein 98
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

La Starza, R., Trubia, M., Crescenzi, B., Matteucci, C., Negrini, M., Martelli, M. F., ... Mecucci, C. (2003). Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13). Genes Chromosomes and Cancer, 36(4), 420-423. https://doi.org/10.1002/gcc.10182

Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13). / La Starza, Roberta; Trubia, Maurizio; Crescenzi, Barbara; Matteucci, Caterina; Negrini, Massimo; Martelli, Massimo F.; Pelicci, Pier Giuseppe; Mecucci, Cristina.

In: Genes Chromosomes and Cancer, Vol. 36, No. 4, 01.04.2003, p. 420-423.

Research output: Contribution to journalArticle

La Starza, R, Trubia, M, Crescenzi, B, Matteucci, C, Negrini, M, Martelli, MF, Pelicci, PG & Mecucci, C 2003, 'Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)', Genes Chromosomes and Cancer, vol. 36, no. 4, pp. 420-423. https://doi.org/10.1002/gcc.10182
La Starza, Roberta ; Trubia, Maurizio ; Crescenzi, Barbara ; Matteucci, Caterina ; Negrini, Massimo ; Martelli, Massimo F. ; Pelicci, Pier Giuseppe ; Mecucci, Cristina. / Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13). In: Genes Chromosomes and Cancer. 2003 ; Vol. 36, No. 4. pp. 420-423.
@article{1bd081089d7a45f48dc2a5dacfcab3d9,
title = "Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)",
abstract = "The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15; q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q 13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies.",
author = "{La Starza}, Roberta and Maurizio Trubia and Barbara Crescenzi and Caterina Matteucci and Massimo Negrini and Martelli, {Massimo F.} and Pelicci, {Pier Giuseppe} and Cristina Mecucci",
year = "2003",
month = "4",
day = "1",
doi = "10.1002/gcc.10182",
language = "English",
volume = "36",
pages = "420--423",
journal = "Genes Chromosomes and Cancer",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)

AU - La Starza, Roberta

AU - Trubia, Maurizio

AU - Crescenzi, Barbara

AU - Matteucci, Caterina

AU - Negrini, Massimo

AU - Martelli, Massimo F.

AU - Pelicci, Pier Giuseppe

AU - Mecucci, Cristina

PY - 2003/4/1

Y1 - 2003/4/1

N2 - The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15; q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q 13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies.

AB - The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15; q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q 13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies.

UR - http://www.scopus.com/inward/record.url?scp=0037375919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037375919&partnerID=8YFLogxK

U2 - 10.1002/gcc.10182

DO - 10.1002/gcc.10182

M3 - Article

C2 - 12619167

AN - SCOPUS:0037375919

VL - 36

SP - 420

EP - 423

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

SN - 1045-2257

IS - 4

ER -