Human homeobox gene HOXCI3 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)

Roberta La Starza, Maurizio Trubia, Barbara Crescenzi, Caterina Matteucci, Massimo Negrini, Massimo F. Martelli, Pier Giuseppe Pelicci, Cristina Mecucci

Research output: Contribution to journalArticlepeer-review

Abstract

The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15; q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q 13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies.

Original languageEnglish
Pages (from-to)420-423
Number of pages4
JournalGenes Chromosomes and Cancer
Volume36
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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