Human homologue of moloney leukemia virus integration-4 locus (MLVI-4), located 20 kilobases 3′ of the myc gene, is rearranged in multiple myelomas

Antonio P. Palumbo, Mario Boccadoro, Silvano Battaglio, Paolo Corradini, Philip N. Tsichlis, Kay Huebner, Alessandro Pileri, Carlo M. Croce

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Abstract

The structure of the c-myc locus and the flanking chromosomal region was investigated by Southern blot analysis of DNA from bone marrow aspirates from 42 patients with multiple myeloma. The main abnormality detected was the rearrangement of the MLV 1-4 locus, 20 kilobases 3′ of c-myc, which was observed in seven cases (16%). Two of these rearrangements were detected at the time of the initial diagnosis, four during treatment, and one at relapse, and their presence correlated with unresponsiveness to therapy. The MLVI-4 locus represents the human homologue of the Moloney leukemia virus integration-4 locus (Mlvi-4), a common region for provirus integration in Moloney murine leukemia virus-induced T-cell lymphomas in rodents. Provirus integration in this locus activates c-myc, and two additional genes, Mlvi-4 and Mlvi-1. The c-myc gene was rearranged in one patient; mutations involving the first exon of c-myc, frequently detected by altered restriction enzyme recognition sites in Burkitt's lymphomas, were not observed in these myelomas.

Original languageEnglish
Pages (from-to)6478-6482
Number of pages5
JournalCancer Research
Volume50
Issue number20
Publication statusPublished - Oct 15 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Palumbo, A. P., Boccadoro, M., Battaglio, S., Corradini, P., Tsichlis, P. N., Huebner, K., Pileri, A., & Croce, C. M. (1990). Human homologue of moloney leukemia virus integration-4 locus (MLVI-4), located 20 kilobases 3′ of the myc gene, is rearranged in multiple myelomas. Cancer Research, 50(20), 6478-6482.