Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy

M. Franzetti; M. Violin; G. Casazza; G. Meini; A. Callegaro; P. Corsi; F. Maggiolo; A. R. Pignataro; S. Paolucci; N. Gianotti; D. Francisci; R. Rossotti; G. Filice; T. Carli; M. Zazzi; C. Balotta

doi:10.1111/j.1469-0691.2011.03740.x

Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy

M. Franzetti, M. Violin, G. Casazza, G. Meini, A. Callegaro, P. Corsi, F. Maggiolo, A. R. Pignataro, S. Paolucci, N. Gianotti, D. Francisci, R. Rossotti, G. Filice, T. Carli, M. Zazzi, C. Balotta

Research output: Contribution to journal › Article › peer-review

Abstract

We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naïve patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.

Original language	English
Journal	Clinical Microbiology and Infection
Volume	18
Issue number	3
DOIs	https://doi.org/10.1111/j.1469-0691.2011.03740.x
Publication status	Published - Mar 2012

Keywords

Antiretroviral treatment
Drug resistance
HIV-1
HIV-1 evolution
Non-B subtypes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1111/j.1469-0691.2011.03740.x

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Franzetti, M., Violin, M., Casazza, G., Meini, G., Callegaro, A., Corsi, P., Maggiolo, F., Pignataro, A. R., Paolucci, S., Gianotti, N., Francisci, D., Rossotti, R., Filice, G., Carli, T., Zazzi, M., & Balotta, C. (2012). Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy. Clinical Microbiology and Infection, 18(3). https://doi.org/10.1111/j.1469-0691.2011.03740.x

Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy. / Franzetti, M.; Violin, M.; Casazza, G.; Meini, G.; Callegaro, A.; Corsi, P.; Maggiolo, F.; Pignataro, A. R.; Paolucci, S.; Gianotti, N.; Francisci, D.; Rossotti, R.; Filice, G.; Carli, T.; Zazzi, M.; Balotta, C.

In: Clinical Microbiology and Infection, Vol. 18, No. 3, 03.2012.

Research output: Contribution to journal › Article › peer-review

Franzetti, M, Violin, M, Casazza, G, Meini, G, Callegaro, A, Corsi, P, Maggiolo, F, Pignataro, AR, Paolucci, S , Gianotti, N, Francisci, D, Rossotti, R, Filice, G, Carli, T, Zazzi, M & Balotta, C 2012, 'Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy', Clinical Microbiology and Infection, vol. 18, no. 3. https://doi.org/10.1111/j.1469-0691.2011.03740.x

Franzetti, M. ; Violin, M. ; Casazza, G. ; Meini, G. ; Callegaro, A. ; Corsi, P. ; Maggiolo, F. ; Pignataro, A. R. ; Paolucci, S. ; Gianotti, N. ; Francisci, D. ; Rossotti, R. ; Filice, G. ; Carli, T. ; Zazzi, M. ; Balotta, C. / Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy. In: Clinical Microbiology and Infection. 2012 ; Vol. 18, No. 3.

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abstract = "We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in na{\"i}ve patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.",

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Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy

Abstract

Keywords

ASJC Scopus subject areas

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