Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy

M. Franzetti, M. Violin, G. Casazza, G. Meini, A. Callegaro, P. Corsi, F. Maggiolo, A. R. Pignataro, S. Paolucci, N. Gianotti, D. Francisci, R. Rossotti, G. Filice, T. Carli, M. Zazzi, C. Balotta

Research output: Contribution to journalArticle

Abstract

We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naïve patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.

Original languageEnglish
JournalClinical Microbiology and Infection
Volume18
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Antiretroviral treatment
  • Drug resistance
  • HIV-1
  • HIV-1 evolution
  • Non-B subtypes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy'. Together they form a unique fingerprint.

  • Cite this

    Franzetti, M., Violin, M., Casazza, G., Meini, G., Callegaro, A., Corsi, P., Maggiolo, F., Pignataro, A. R., Paolucci, S., Gianotti, N., Francisci, D., Rossotti, R., Filice, G., Carli, T., Zazzi, M., & Balotta, C. (2012). Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy. Clinical Microbiology and Infection, 18(3). https://doi.org/10.1111/j.1469-0691.2011.03740.x