Human immunodeficiency virus-associated precursor T-lymphoblastic leukemia/lymphoblastic lymphoma: report of a case and review of the literature

Debora Lorenzon, Tiziana Perin, Pietro Bulian, Valli De Re, Laura Caggiari, Mariagrazia Michieli, Rosa Manuele, Michele Spina, Valter Gattei, Marco Fasan, Umberto Tirelli, Vincenzo Canzonieri

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a case of human immunodeficiency virus-associated T-lymphoblastic leukemia/lymphoblastic lymphoma in a 43-year-old Italian man with a history of human immunodeficiency virus infection lasting 9 years. Immunoperoxidase stains showed that neoplastic cells were positive for CD3, TdT, CD45, CD10, CD1a, CD2, CD7, CD5, and CD43 (focal). The proliferation rate was approximately 70%, assessed by Ki-67/MIB-1 staining. Flow cytometry of the marrow aspirate revealed an intermediate/cortical T-lymphoblastic phenotype: negative for surface CD3 and positive for cytoplasmic CD3, CD1a, TdT, CD2, CD7, CD5, and CD8, with partial coexpression of dimCD4. Analysis of T-cell receptor γ polymerase chain reaction products showed clonality. T-lymphoblastic leukemia/lymphoblastic lymphoma is a very rare occurrence in the clinical setting of human immunodeficiency virus infection. It is not listed in the World Health Organization classification of lymphomas associated with human immunodeficiency virus infection. Only 4 cases of human immunodeficiency virus-associated T-lymphoblastic leukemia/lymphoblastic lymphoma are reported in the current medical literature.

Original languageEnglish
Pages (from-to)1045-1049
Number of pages5
JournalHuman Pathology
Volume40
Issue number7
DOIs
Publication statusPublished - Jul 2009

Keywords

  • HIV
  • Precursor T-lymphoblastic leukemia/lymphoblastic lymphoma
  • T-LBL

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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