Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons

Sandra Mazzoli, Lucia Lopalco, Alessandra Salvi, Daria Trabattoni, Sergio Lo Caputo, Francesca Semplici, Mara Biasin, Claudio Blé, Antonio Cosma, Claudia Pastori, Francesca Meacci, Francesco Mazzotta, Maria Luisa Villa, Antonio G. Siccardi, Mario Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

The presence and activity of human immunodeficiency virus (HIV)-specific antibodies were analyzed in the sera of 15 sexually exposed seronegative persons who had Systemic HIV-specific cell-mediated immunity and IgA-mediated mucosal immunity and in their HIV-infected partners. The HIV-positive subjects had HIV-specific serum IgG and IgA; the seronegative persons had HIV-specific serum IgA in the absence of IgG. Testing of the seronegative persons 1 year after the interruption of at-risk sex showed that no IgG seroconversion had occurred and that HIV-specific IgA serum concentrations had declined. Serum from the HIV-exposed seronegative persons was analyzed for the ability to neutralize primary HIV-1 isolates. Neutralizing activity was detected in 5 of 15 sera and in 2 cases was retained by serum-purified IgA. Thus, the immunologic picture for resistance to HIV infection should include HIV-specific cell-mediated immunity as well as HIV-specific IgA- mediated mucosal and systemic immunity.

Original languageEnglish
Pages (from-to)871-875
Number of pages5
JournalJournal of Infectious Diseases
Volume180
Issue number3
DOIs
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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