Human immunodeficiency virus infection in the US air force: Seroconversions, clinical staging, and assessment of a T helper cell functional assay to predict change in CD4+ T cell counts

Daniel R. Lucey, Gregory P. Melcher, Craig W. Hendrix, Robert A. Zajac, David W. Goetz, Clifford A. Butzin, Mario Clerici, Ronald D. Warner, Steven Abbadessa, Kevin Hall, Rene Jaso, Brian Woolford, Shirley Miller, Naomi I. Stocks, Cynthia M. Salinas, William H. Wolfe, Gene M. Shearer, R. Neal Boswell

Research output: Contribution to journalArticle

Abstract

As of January 1990, 933 persons with human immunodeficiency virus type 1 (HIV-1) infection were clinically evaluated at Wilford Hall US Air Force (USAF) Medical Center. The Walter Reed HIV staging system was used in these evaluations to describe disease status and progression. Most persons were diagnosed through mandatory HIV testing in the USAF and were asymptomatic at the time of diagnosis. As of May 1990, 161 HIV-positive seroconverters (estimated overall seroconversion rate of 0.156/1000 person-years between 30 June 1988 and 1 July 1990) had been identified among active-duty USAF personnel, as they had previously tested negative for antibody to HIV. Men constitute 95% of the USAF HIV-positive population. An in vitro T helper cell functional assay was assessed to predict rate of CD4+ T cell decline over the subsequent year (mean, 15 months) in patients with >200 CD4+ T cells/mm3. This assay may prove useful for prognostication and comparisons of patients in clinical trials of anti-HIV interventions.

Original languageEnglish
Pages (from-to)631-637
Number of pages7
JournalJournal of Infectious Diseases
Volume164
Issue number4
Publication statusPublished - Oct 1991

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Virus Diseases
CD4 Lymphocyte Count
Helper-Inducer T-Lymphocytes
Air
HIV
T-Lymphocytes
Mandatory Testing
HIV Antibodies
Military Personnel
Disease Progression
HIV-1
Seroconversion
Clinical Trials
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Human immunodeficiency virus infection in the US air force : Seroconversions, clinical staging, and assessment of a T helper cell functional assay to predict change in CD4+ T cell counts. / Lucey, Daniel R.; Melcher, Gregory P.; Hendrix, Craig W.; Zajac, Robert A.; Goetz, David W.; Butzin, Clifford A.; Clerici, Mario; Warner, Ronald D.; Abbadessa, Steven; Hall, Kevin; Jaso, Rene; Woolford, Brian; Miller, Shirley; Stocks, Naomi I.; Salinas, Cynthia M.; Wolfe, William H.; Shearer, Gene M.; Boswell, R. Neal.

In: Journal of Infectious Diseases, Vol. 164, No. 4, 10.1991, p. 631-637.

Research output: Contribution to journalArticle

Lucey, DR, Melcher, GP, Hendrix, CW, Zajac, RA, Goetz, DW, Butzin, CA, Clerici, M, Warner, RD, Abbadessa, S, Hall, K, Jaso, R, Woolford, B, Miller, S, Stocks, NI, Salinas, CM, Wolfe, WH, Shearer, GM & Boswell, RN 1991, 'Human immunodeficiency virus infection in the US air force: Seroconversions, clinical staging, and assessment of a T helper cell functional assay to predict change in CD4+ T cell counts', Journal of Infectious Diseases, vol. 164, no. 4, pp. 631-637.
Lucey, Daniel R. ; Melcher, Gregory P. ; Hendrix, Craig W. ; Zajac, Robert A. ; Goetz, David W. ; Butzin, Clifford A. ; Clerici, Mario ; Warner, Ronald D. ; Abbadessa, Steven ; Hall, Kevin ; Jaso, Rene ; Woolford, Brian ; Miller, Shirley ; Stocks, Naomi I. ; Salinas, Cynthia M. ; Wolfe, William H. ; Shearer, Gene M. ; Boswell, R. Neal. / Human immunodeficiency virus infection in the US air force : Seroconversions, clinical staging, and assessment of a T helper cell functional assay to predict change in CD4+ T cell counts. In: Journal of Infectious Diseases. 1991 ; Vol. 164, No. 4. pp. 631-637.
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