Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans

Correlation with a cytotoxic T cell epitope

Anne S. De Groot, Mario Clerici, Anne Hosmalin, Stephen H. Hughes, Donna Barnd, Craig W. Hendrix, Richard Houghten, Gene M. Shearer, Jay A. Berzofsky

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

T cell immunity may be critical to development of a vaccine for human immunodeficiency virus (HIV-1). T helper epitopes were identified in three predominantly conserved regions in the HIV-1 reverse transcriptase by using reverse transcriptase-immunized mice of five major histocompatibility complex haplotypes. One peptide (residues 38-52) that stimulated H-2k T cells also contained an epitope recognized by cytotoxic T cells from the same mice and from HIV-infected patients. Such concordance between helper and cytotoxic T lymphocyte epitopes, observed in four cases, may be important in vaccine development. Peptide 36-52 was recognized by interleukin-2-producing peripheral blood T cells from 9 of 17 HIV-seropositive humans studied, of multiple human leukocyte antigen-DR and -DQ types. The broad recognition of this peptide by both helper and cytotoxic T cells substantiates its potential importance in a vaccine.

Original languageEnglish
Pages (from-to)1058-1065
Number of pages8
JournalJournal of Infectious Diseases
Volume164
Issue number6
Publication statusPublished - Dec 1991

Fingerprint

HIV Reverse Transcriptase
T-Lymphocyte Epitopes
Epitopes
T-Lymphocytes
Vaccines
Helper-Inducer T-Lymphocytes
Peptides
HIV-1
HIV
RNA-Directed DNA Polymerase
Cytotoxic T-Lymphocytes
HLA Antigens
Major Histocompatibility Complex
Haplotypes
Interleukin-2
Immunity
Blood Cells

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

De Groot, A. S., Clerici, M., Hosmalin, A., Hughes, S. H., Barnd, D., Hendrix, C. W., ... Berzofsky, J. A. (1991). Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: Correlation with a cytotoxic T cell epitope. Journal of Infectious Diseases, 164(6), 1058-1065.

Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans : Correlation with a cytotoxic T cell epitope. / De Groot, Anne S.; Clerici, Mario; Hosmalin, Anne; Hughes, Stephen H.; Barnd, Donna; Hendrix, Craig W.; Houghten, Richard; Shearer, Gene M.; Berzofsky, Jay A.

In: Journal of Infectious Diseases, Vol. 164, No. 6, 12.1991, p. 1058-1065.

Research output: Contribution to journalArticle

De Groot, AS, Clerici, M, Hosmalin, A, Hughes, SH, Barnd, D, Hendrix, CW, Houghten, R, Shearer, GM & Berzofsky, JA 1991, 'Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans: Correlation with a cytotoxic T cell epitope', Journal of Infectious Diseases, vol. 164, no. 6, pp. 1058-1065.
De Groot, Anne S. ; Clerici, Mario ; Hosmalin, Anne ; Hughes, Stephen H. ; Barnd, Donna ; Hendrix, Craig W. ; Houghten, Richard ; Shearer, Gene M. ; Berzofsky, Jay A. / Human immunodeficiency virus reverse transcriptase T helper epitopes identified in mice and humans : Correlation with a cytotoxic T cell epitope. In: Journal of Infectious Diseases. 1991 ; Vol. 164, No. 6. pp. 1058-1065.
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