TY - JOUR
T1 - Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells
AU - Del Cornò, Manuela
AU - Gauzzi, Maria Cristina
AU - Penna, Giuseppe
AU - Belardelli, Filippo
AU - Adorini, Luciano
AU - Gessani, Sandra
PY - 2005/10
Y1 - 2005/10
N2 - Exposure to aldrithiol-2-inactivated human immunodeficiency virus type 1 or gp120, but not gp41, triggered alpha interferon (IFN-α), CC chemokine ligand 2 (CCL2), CCL3, and CCL4 production in human plasmacytoid dendritic cells (DCs) but not in myeloid DCs (M-DCs) or monocyte-derived DCs from the same donors. The nonresponsiveness of M-DCs for IFN-α/β production was a general feature specific to these cells, as they also failed to produce it in response to inactivated influenza virus, poly(I-C), lipopolysaccharide, Staphylococcus aureus Cowans I, or CD40L. The different capacities of circulating DC subsets to produce immune mediators in response to most stimuli argue for a different role for these cells in the regulation of innate immunity to pathogens.
AB - Exposure to aldrithiol-2-inactivated human immunodeficiency virus type 1 or gp120, but not gp41, triggered alpha interferon (IFN-α), CC chemokine ligand 2 (CCL2), CCL3, and CCL4 production in human plasmacytoid dendritic cells (DCs) but not in myeloid DCs (M-DCs) or monocyte-derived DCs from the same donors. The nonresponsiveness of M-DCs for IFN-α/β production was a general feature specific to these cells, as they also failed to produce it in response to inactivated influenza virus, poly(I-C), lipopolysaccharide, Staphylococcus aureus Cowans I, or CD40L. The different capacities of circulating DC subsets to produce immune mediators in response to most stimuli argue for a different role for these cells in the regulation of innate immunity to pathogens.
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U2 - 10.1128/JVI.79.19.12597-12601.2005
DO - 10.1128/JVI.79.19.12597-12601.2005
M3 - Article
C2 - 16160188
AN - SCOPUS:25144439496
VL - 79
SP - 12597
EP - 12601
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 19
ER -