Human immunodeficiency virus type 1 (HIV-1) and human hematopoietic progenitor cells

M. C. Re, G. Furlini, G. Zauli, M. La Placa

Research output: Contribution to journalArticle

Abstract

Besides a progressive depletion of CD4+ T-lymphocytes, other peripheral blood cytopenias, (granulocytopenia, anemia and thrombocytopenia) are frequently observed in HIV-1 seropositive individuals, especially in patients with overt AIDS. Various experimental evidences suggest that HIV-1 could play a direct role in the pathogenesis of HIV-1 related peripheral blood cytopenias, affecting the survival/proliferation capacity of hematopoietic progenitors. CD34+ human hematopoietic progenitors, however, are substantially not susceptible to HIV-1 infection either in vitro and in vivo and their defects seem rather related to an alteration of bone marrow and peripheral blood microenvironments due to the presence of soluble HIV-1 specific products.

Original languageEnglish
Pages (from-to)1-23
Number of pages23
JournalArchives of Virology
Volume137
Issue number1-2
DOIs
Publication statusPublished - Mar 1994

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

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