Human immunodeficiency virus type 1 intersubtype recombinants predominate in the AIDS epidemic in Cameroon

Judith N. Torimiro, Roberta D'Arrigo, Desire Takou, Aubin Nanfack, Daniele Pizzi, Innocent Ngong, Jean K. Carr, Fouda Pierre Joseph, Carlo Federico Perno, Giulia Cappelli

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A broad and rapidly changing HIV Type 1 (HIV-1) diversity has been reported from different populations in Cameroon since the early epidemic. Our understanding of HIV-1 dynamics can be improved by a systematic surveillance in Cameroon as accessibility and use of antiretroviral drugs increase. To contribute to this, we genotyped 30 samples by sequencing the protease and reverse transcriptase (proRT) genes of HIV-1. Phylogenetic analysis of the HIV-1 proRT sequences using the MEGA3 software showed that 26 (86.7%) were recombinant forms which included 20 (66.7%) circulating recombinant forms: CRF02-AG, (50%), CRF06-cpx (3.3%), CRF11-cpx (10%) and CRF37-cpx (3.3%), and 6 unique recombinant forms (URF, 20%). Two of the six URFs were second generation recombinants and 4 contained unclassified segments. HIV-1 subtypes Al (3.3%), C (3.3%) and D (6.7%) were also identified. Although partial sequences of HIV-1 genome were analysed, our results indicate that recombinant HIV-1 variants predominate in the AIDS epidemic in Cameroon. With the widespread use of antiretroviral drugs in Cameroon and the circulation of several HIV-1 variants within this population, the emergence of recombinants with unknown diagnostic and clinical consequences is a concern.

Original languageEnglish
Pages (from-to)325-332
Number of pages8
JournalNew Microbiologica
Volume32
Issue number4
Publication statusPublished - Oct 2009

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Cameroon
HIV-1
Acquired Immunodeficiency Syndrome
RNA-Directed DNA Polymerase
Pharmaceutical Preparations
Population
Peptide Hydrolases
Software
Genome
Genes

Keywords

  • Cameroon
  • Diversity
  • HIV
  • Recombinant forms

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Torimiro, J. N., D'Arrigo, R., Takou, D., Nanfack, A., Pizzi, D., Ngong, I., ... Cappelli, G. (2009). Human immunodeficiency virus type 1 intersubtype recombinants predominate in the AIDS epidemic in Cameroon. New Microbiologica, 32(4), 325-332.

Human immunodeficiency virus type 1 intersubtype recombinants predominate in the AIDS epidemic in Cameroon. / Torimiro, Judith N.; D'Arrigo, Roberta; Takou, Desire; Nanfack, Aubin; Pizzi, Daniele; Ngong, Innocent; Carr, Jean K.; Joseph, Fouda Pierre; Perno, Carlo Federico; Cappelli, Giulia.

In: New Microbiologica, Vol. 32, No. 4, 10.2009, p. 325-332.

Research output: Contribution to journalArticle

Torimiro, JN, D'Arrigo, R, Takou, D, Nanfack, A, Pizzi, D, Ngong, I, Carr, JK, Joseph, FP, Perno, CF & Cappelli, G 2009, 'Human immunodeficiency virus type 1 intersubtype recombinants predominate in the AIDS epidemic in Cameroon', New Microbiologica, vol. 32, no. 4, pp. 325-332.
Torimiro, Judith N. ; D'Arrigo, Roberta ; Takou, Desire ; Nanfack, Aubin ; Pizzi, Daniele ; Ngong, Innocent ; Carr, Jean K. ; Joseph, Fouda Pierre ; Perno, Carlo Federico ; Cappelli, Giulia. / Human immunodeficiency virus type 1 intersubtype recombinants predominate in the AIDS epidemic in Cameroon. In: New Microbiologica. 2009 ; Vol. 32, No. 4. pp. 325-332.
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