Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis

G. Zauli, D. Gibellini, D. Milani, M. Mazzoni, P. Borgatti, M. La Placa, S. Capitani

Research output: Contribution to journalArticlepeer-review

Abstract

We report here that the tat gene product of human immunodeficiency virus type 1 was able to protect lymphoblastoid (Jurkat), epithelial (293) and neuronal (PC12) cell lines from apoptotic death induced by serum withdrawal. The rescue from apoptosis by Tat was reflected by an increased expression of Bcl-2 protein in tat-positive Jurkat cells with respect to mock-transfected Jurkat cells after 3-6 days of serum-free cultures. We propose that the ability of the regulatory human immunodeficiency virus type 1 Tat protein to suppress apoptosis might have important implications in understanding the pathogenesis of frequent neoplastic disorders observed in human immunodeficiency virus type 1-seropositive individuals.

Original languageEnglish
Pages (from-to)4481-4485
Number of pages5
JournalCancer Research
Volume53
Issue number18
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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