Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen

Stephanie Kruetzmann, M. Manuela Rosado, Holger Weber, Ulrich Germing, Olivier Tournilhac, Hans Hartmut Peter, Reinhard Berner, Anke Peters, Thomas Boehm, Alessandro Plebani, Isabella Quinti, Rita Carsetti

Research output: Contribution to journalArticle

454 Citations (Scopus)

Abstract

Splenectomized and asplenic patients have a high incidence of infections by encapsulated bacteria and do not respond to polysaccharide vaccines. To understand whether the absence of the spleen is associated with a defined B cell defect, we analyzed B cell subsets in the peripheral blood. We found that a population of B cells known as immunoglobulin (Ig)M memory is lacking in patients without spleen. The absence of IgM memory B cells correlates with an impaired immune response to encapsulated bacteria not only in splenectomized patients, but also in individuals with an intact spleen. We show that the physiological and transient predisposition to pneumococcal infections of young children (0-2 yr) is associated with the lack of circulating IgM memory B cells and of serum antipolysaccharide IgM. We also demonstrate that IgM memory B cells are undetectable in a fraction of patients with common variable immunodeficiency, who have recurrent and invasive infections by encapsulated bacteria. IgM memory B cells, therefore, require the spleen for their generation and/or survival and are responsible for the protection against encapsulated bacteria.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalJournal of Experimental Medicine
Volume197
Issue number7
DOIs
Publication statusPublished - Apr 2003

Fingerprint

Pneumococcal Infections
Immunoglobulin M
B-Lymphocytes
Spleen
Bacteria
Common Variable Immunodeficiency
B-Lymphocyte Subsets
Infection
Polysaccharides
Vaccines
Survival
Incidence
Serum
Population

Keywords

  • Asplenia
  • B cells
  • Infants
  • Polysaccharide vaccines
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Immunology

Cite this

Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. / Kruetzmann, Stephanie; Rosado, M. Manuela; Weber, Holger; Germing, Ulrich; Tournilhac, Olivier; Peter, Hans Hartmut; Berner, Reinhard; Peters, Anke; Boehm, Thomas; Plebani, Alessandro; Quinti, Isabella; Carsetti, Rita.

In: Journal of Experimental Medicine, Vol. 197, No. 7, 04.2003, p. 939-945.

Research output: Contribution to journalArticle

Kruetzmann, S, Rosado, MM, Weber, H, Germing, U, Tournilhac, O, Peter, HH, Berner, R, Peters, A, Boehm, T, Plebani, A, Quinti, I & Carsetti, R 2003, 'Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen', Journal of Experimental Medicine, vol. 197, no. 7, pp. 939-945. https://doi.org/10.1084/jem.20022020
Kruetzmann, Stephanie ; Rosado, M. Manuela ; Weber, Holger ; Germing, Ulrich ; Tournilhac, Olivier ; Peter, Hans Hartmut ; Berner, Reinhard ; Peters, Anke ; Boehm, Thomas ; Plebani, Alessandro ; Quinti, Isabella ; Carsetti, Rita. / Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. In: Journal of Experimental Medicine. 2003 ; Vol. 197, No. 7. pp. 939-945.
@article{446467db69d54bdb9c0dc0489258eaac,
title = "Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen",
abstract = "Splenectomized and asplenic patients have a high incidence of infections by encapsulated bacteria and do not respond to polysaccharide vaccines. To understand whether the absence of the spleen is associated with a defined B cell defect, we analyzed B cell subsets in the peripheral blood. We found that a population of B cells known as immunoglobulin (Ig)M memory is lacking in patients without spleen. The absence of IgM memory B cells correlates with an impaired immune response to encapsulated bacteria not only in splenectomized patients, but also in individuals with an intact spleen. We show that the physiological and transient predisposition to pneumococcal infections of young children (0-2 yr) is associated with the lack of circulating IgM memory B cells and of serum antipolysaccharide IgM. We also demonstrate that IgM memory B cells are undetectable in a fraction of patients with common variable immunodeficiency, who have recurrent and invasive infections by encapsulated bacteria. IgM memory B cells, therefore, require the spleen for their generation and/or survival and are responsible for the protection against encapsulated bacteria.",
keywords = "Asplenia, B cells, Infants, Polysaccharide vaccines, Streptococcus pneumoniae",
author = "Stephanie Kruetzmann and Rosado, {M. Manuela} and Holger Weber and Ulrich Germing and Olivier Tournilhac and Peter, {Hans Hartmut} and Reinhard Berner and Anke Peters and Thomas Boehm and Alessandro Plebani and Isabella Quinti and Rita Carsetti",
year = "2003",
month = "4",
doi = "10.1084/jem.20022020",
language = "English",
volume = "197",
pages = "939--945",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "7",

}

TY - JOUR

T1 - Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen

AU - Kruetzmann, Stephanie

AU - Rosado, M. Manuela

AU - Weber, Holger

AU - Germing, Ulrich

AU - Tournilhac, Olivier

AU - Peter, Hans Hartmut

AU - Berner, Reinhard

AU - Peters, Anke

AU - Boehm, Thomas

AU - Plebani, Alessandro

AU - Quinti, Isabella

AU - Carsetti, Rita

PY - 2003/4

Y1 - 2003/4

N2 - Splenectomized and asplenic patients have a high incidence of infections by encapsulated bacteria and do not respond to polysaccharide vaccines. To understand whether the absence of the spleen is associated with a defined B cell defect, we analyzed B cell subsets in the peripheral blood. We found that a population of B cells known as immunoglobulin (Ig)M memory is lacking in patients without spleen. The absence of IgM memory B cells correlates with an impaired immune response to encapsulated bacteria not only in splenectomized patients, but also in individuals with an intact spleen. We show that the physiological and transient predisposition to pneumococcal infections of young children (0-2 yr) is associated with the lack of circulating IgM memory B cells and of serum antipolysaccharide IgM. We also demonstrate that IgM memory B cells are undetectable in a fraction of patients with common variable immunodeficiency, who have recurrent and invasive infections by encapsulated bacteria. IgM memory B cells, therefore, require the spleen for their generation and/or survival and are responsible for the protection against encapsulated bacteria.

AB - Splenectomized and asplenic patients have a high incidence of infections by encapsulated bacteria and do not respond to polysaccharide vaccines. To understand whether the absence of the spleen is associated with a defined B cell defect, we analyzed B cell subsets in the peripheral blood. We found that a population of B cells known as immunoglobulin (Ig)M memory is lacking in patients without spleen. The absence of IgM memory B cells correlates with an impaired immune response to encapsulated bacteria not only in splenectomized patients, but also in individuals with an intact spleen. We show that the physiological and transient predisposition to pneumococcal infections of young children (0-2 yr) is associated with the lack of circulating IgM memory B cells and of serum antipolysaccharide IgM. We also demonstrate that IgM memory B cells are undetectable in a fraction of patients with common variable immunodeficiency, who have recurrent and invasive infections by encapsulated bacteria. IgM memory B cells, therefore, require the spleen for their generation and/or survival and are responsible for the protection against encapsulated bacteria.

KW - Asplenia

KW - B cells

KW - Infants

KW - Polysaccharide vaccines

KW - Streptococcus pneumoniae

UR - http://www.scopus.com/inward/record.url?scp=0345269199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345269199&partnerID=8YFLogxK

U2 - 10.1084/jem.20022020

DO - 10.1084/jem.20022020

M3 - Article

C2 - 12682112

AN - SCOPUS:0345269199

VL - 197

SP - 939

EP - 945

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 7

ER -