Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen

Stephanie Kruetzmann, M. Manuela Rosado, Holger Weber, Ulrich Germing, Olivier Tournilhac, Hans Hartmut Peter, Reinhard Berner, Anke Peters, Thomas Boehm, Alessandro Plebani, Isabella Quinti, Rita Carsetti

Research output: Contribution to journalArticle

Abstract

Splenectomized and asplenic patients have a high incidence of infections by encapsulated bacteria and do not respond to polysaccharide vaccines. To understand whether the absence of the spleen is associated with a defined B cell defect, we analyzed B cell subsets in the peripheral blood. We found that a population of B cells known as immunoglobulin (Ig)M memory is lacking in patients without spleen. The absence of IgM memory B cells correlates with an impaired immune response to encapsulated bacteria not only in splenectomized patients, but also in individuals with an intact spleen. We show that the physiological and transient predisposition to pneumococcal infections of young children (0-2 yr) is associated with the lack of circulating IgM memory B cells and of serum antipolysaccharide IgM. We also demonstrate that IgM memory B cells are undetectable in a fraction of patients with common variable immunodeficiency, who have recurrent and invasive infections by encapsulated bacteria. IgM memory B cells, therefore, require the spleen for their generation and/or survival and are responsible for the protection against encapsulated bacteria.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalJournal of Experimental Medicine
Volume197
Issue number7
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Asplenia
  • B cells
  • Infants
  • Polysaccharide vaccines
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Immunology

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    Kruetzmann, S., Rosado, M. M., Weber, H., Germing, U., Tournilhac, O., Peter, H. H., Berner, R., Peters, A., Boehm, T., Plebani, A., Quinti, I., & Carsetti, R. (2003). Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. Journal of Experimental Medicine, 197(7), 939-945. https://doi.org/10.1084/jem.20022020