Human in vitro allogeneic responses: Demonstration of three pathways of T helper cell activation

Charles S. Via, George C. Tsokos, Naomi I. Stocks, Mario Clerici, Gene M. Shearer

Research output: Contribution to journalArticle

Abstract

In our study, we have measured in vitro proliferation and IL-2 production by human PBL to characterize the interactions between Th cells and accessory cells (AC) involved in responses to either conventional Ag or alloantigens. IL-2 production and proliferative responses to conventional Ag, such as influenza or tetanus, are exclusively dependent on the presence of CD4+ T cells and AC. In contrast, IL-2 and proliferative responses to alloantigen can be mediated by either CD4+ or CD8+ T cells. CD4+ T cells respond to alloantigen using either autologous AC (self-restricted), or allogeneic AC (allo-restricted), whereas CD8+ T cells respond to alloantigen using allogeneic AC only. The understanding of Th cell-AC interactions involved in in vitro allogeneic responses will be important for delineating the Th cell-AC interactions involved in transplantation immunity as well as in clinical disorders characterized by T cell dysfunction such as human immunodeficiency virus infection and systemic lupus erythematosus.

Original languageEnglish
Pages (from-to)2524-2528
Number of pages5
JournalJournal of Immunology
Volume144
Issue number7
Publication statusPublished - Apr 1 1990

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Helper-Inducer T-Lymphocytes
Isoantigens
T-Lymphocytes
Interleukin-2
Cell Communication
In Vitro Techniques
Tetanus
Virus Diseases
Systemic Lupus Erythematosus
Human Influenza
Immunity
Transplantation
HIV

ASJC Scopus subject areas

  • Immunology

Cite this

Via, C. S., Tsokos, G. C., Stocks, N. I., Clerici, M., & Shearer, G. M. (1990). Human in vitro allogeneic responses: Demonstration of three pathways of T helper cell activation. Journal of Immunology, 144(7), 2524-2528.

Human in vitro allogeneic responses : Demonstration of three pathways of T helper cell activation. / Via, Charles S.; Tsokos, George C.; Stocks, Naomi I.; Clerici, Mario; Shearer, Gene M.

In: Journal of Immunology, Vol. 144, No. 7, 01.04.1990, p. 2524-2528.

Research output: Contribution to journalArticle

Via, CS, Tsokos, GC, Stocks, NI, Clerici, M & Shearer, GM 1990, 'Human in vitro allogeneic responses: Demonstration of three pathways of T helper cell activation', Journal of Immunology, vol. 144, no. 7, pp. 2524-2528.
Via, Charles S. ; Tsokos, George C. ; Stocks, Naomi I. ; Clerici, Mario ; Shearer, Gene M. / Human in vitro allogeneic responses : Demonstration of three pathways of T helper cell activation. In: Journal of Immunology. 1990 ; Vol. 144, No. 7. pp. 2524-2528.
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