TY - JOUR
T1 - Human innate lymphoid cells
AU - Montaldo, Elisa
AU - Vacca, Paola
AU - Vitale, Chiara
AU - Moretta, Francesca
AU - Locatelli, Franco
AU - Mingari, Maria Cristina
AU - Moretta, Lorenzo
PY - 2016/1/11
Y1 - 2016/1/11
N2 - The interest in innate lymphoid cells (ILC) has rapidly grown during the last decade. ILC include distinct cell types that are collectively involved in host protection against pathogens and tumor cells and in the regulation of tissue homeostasis. Studies in mice enabled a broad characterization of ILC function and of their developmental requirements. In humans all mature ILC subsets have been characterized and their role in the pathogenesis of certain disease is emerging. Nonetheless, still limited information is available on human ILC development. Indeed, only the cell precursors committed toward NK cells or ILC3 have been described. Here, we review the most recent finding on human mature ILC, discussing their tissue localization and function. Moreover, we summarize the available data regarding human ILC development.
AB - The interest in innate lymphoid cells (ILC) has rapidly grown during the last decade. ILC include distinct cell types that are collectively involved in host protection against pathogens and tumor cells and in the regulation of tissue homeostasis. Studies in mice enabled a broad characterization of ILC function and of their developmental requirements. In humans all mature ILC subsets have been characterized and their role in the pathogenesis of certain disease is emerging. Nonetheless, still limited information is available on human ILC development. Indeed, only the cell precursors committed toward NK cells or ILC3 have been described. Here, we review the most recent finding on human mature ILC, discussing their tissue localization and function. Moreover, we summarize the available data regarding human ILC development.
KW - HSCT
KW - ILC
KW - ILC development
KW - NK cell differentiation
KW - NK cells
UR - http://www.scopus.com/inward/record.url?scp=84958280162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958280162&partnerID=8YFLogxK
U2 - 10.1016/j.imlet.2016.01.007
DO - 10.1016/j.imlet.2016.01.007
M3 - Article
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
ER -