Human innate lymphoid cells

Elisa Montaldo, Paola Vacca, Chiara Vitale, Francesca Moretta, Franco Locatelli, Maria Cristina Mingari, Lorenzo Moretta

Research output: Contribution to journalArticlepeer-review


The interest in innate lymphoid cells (ILC) has rapidly grown during the last decade. ILC include distinct cell types that are collectively involved in host protection against pathogens and tumor cells and in the regulation of tissue homeostasis. Studies in mice enabled a broad characterization of ILC function and of their developmental requirements. In humans all mature ILC subsets have been characterized and their role in the pathogenesis of certain disease is emerging. Nonetheless, still limited information is available on human ILC development. Indeed, only the cell precursors committed toward NK cells or ILC3 have been described. Here, we review the most recent finding on human mature ILC, discussing their tissue localization and function. Moreover, we summarize the available data regarding human ILC development.

Original languageEnglish
JournalImmunology Letters
Publication statusAccepted/In press - Jan 11 2016


  • HSCT
  • ILC
  • ILC development
  • NK cell differentiation
  • NK cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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