Human innate lymphoid cells

Elisa Montaldo, Paola Vacca, Chiara Vitale, Francesca Moretta, Franco Locatelli, Maria Cristina Mingari, Lorenzo Moretta

Research output: Contribution to journalArticle

Abstract

The interest in innate lymphoid cells (ILC) has rapidly grown during the last decade. ILC include distinct cell types that are collectively involved in host protection against pathogens and tumor cells and in the regulation of tissue homeostasis. Studies in mice enabled a broad characterization of ILC function and of their developmental requirements. In humans all mature ILC subsets have been characterized and their role in the pathogenesis of certain disease is emerging. Nonetheless, still limited information is available on human ILC development. Indeed, only the cell precursors committed toward NK cells or ILC3 have been described. Here, we review the most recent finding on human mature ILC, discussing their tissue localization and function. Moreover, we summarize the available data regarding human ILC development.

Original languageEnglish
JournalImmunology Letters
DOIs
Publication statusAccepted/In press - Jan 11 2016

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Lymphocytes
Natural Killer Cells
Homeostasis
Neoplasms

Keywords

  • HSCT
  • ILC
  • ILC development
  • NK cell differentiation
  • NK cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Montaldo, E., Vacca, P., Vitale, C., Moretta, F., Locatelli, F., Mingari, M. C., & Moretta, L. (Accepted/In press). Human innate lymphoid cells. Immunology Letters. https://doi.org/10.1016/j.imlet.2016.01.007

Human innate lymphoid cells. / Montaldo, Elisa; Vacca, Paola; Vitale, Chiara; Moretta, Francesca; Locatelli, Franco; Mingari, Maria Cristina; Moretta, Lorenzo.

In: Immunology Letters, 11.01.2016.

Research output: Contribution to journalArticle

Montaldo, E, Vacca, P, Vitale, C, Moretta, F, Locatelli, F, Mingari, MC & Moretta, L 2016, 'Human innate lymphoid cells', Immunology Letters. https://doi.org/10.1016/j.imlet.2016.01.007
Montaldo E, Vacca P, Vitale C, Moretta F, Locatelli F, Mingari MC et al. Human innate lymphoid cells. Immunology Letters. 2016 Jan 11. https://doi.org/10.1016/j.imlet.2016.01.007
Montaldo, Elisa ; Vacca, Paola ; Vitale, Chiara ; Moretta, Francesca ; Locatelli, Franco ; Mingari, Maria Cristina ; Moretta, Lorenzo. / Human innate lymphoid cells. In: Immunology Letters. 2016.
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