Human intestinal microbiota: Cross-talk with the host and its potential role in colorectal cancer

Marco Candela, Marco Guidotti, Alessia Fabbri, Patrizia Brigidi, Claudio Franceschi, Carla Fiorentini

Research output: Contribution to journalArticle

Abstract

In this review, we discuss the multifactorial role of intestinal microbiota in colorectal cancer. The peculiar metabolism of dietary compounds of the individual microbiota complement, its overall immunostimulation and immunomodulatory activity, and eventually the production of toxins that perturb the regulation of cell growth, define the balance of positive and negative risk factors for colorectal cancer development. Moreover, shaping the composition of the human intestinal microbiota, diet has an indirect impact in determining the balance between health and disease. The integration of diet, microbial, and host factors in a system approach is mandatory to determine the overall balance of risk and protective factors for colorectal cancer onset.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalCritical Reviews in Microbiology
Volume37
Issue number1
DOIs
Publication statusPublished - Feb 2011

Keywords

  • colorectal cancer
  • diet
  • immune system
  • inflammation
  • Intestinal microbiota

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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