Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes

Roberto Gambari; Laura del Senno; Roberta Piva; Raffaella Barbieri; Francesca Amelotti; Francesco Bernardi; Giovanna Marchetti; Franca Citarella; Marco Tripodi; Antonio Fantoni

doi:10.1016/S0006-291X(84)80338-1

Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes

Roberto Gambari, Laura del Senno, Roberta Piva, Raffaella Barbieri, Francesca Amelotti, Francesco Bernardi, Giovanna Marchetti, Franca Citarella, Marco Tripodi, Antonio Fantoni

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level.

Original language	English
Pages (from-to)	90-96
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	125
Issue number	1
DOIs	https://doi.org/10.1016/S0006-291X(84)80338-1
Publication status	Published - Nov 30 1984

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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Gambari, R., del Senno, L., Piva, R., Barbieri, R., Amelotti, F., Bernardi, F., Marchetti, G., Citarella, F., Tripodi, M., & Fantoni, A. (1984). Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes. Biochemical and Biophysical Research Communications, 125(1), 90-96. https://doi.org/10.1016/S0006-291X(84)80338-1

Human leukemia K562 cells : Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes. / Gambari, Roberto; del Senno, Laura; Piva, Roberta; Barbieri, Raffaella; Amelotti, Francesca; Bernardi, Francesco; Marchetti, Giovanna; Citarella, Franca; Tripodi, Marco; Fantoni, Antonio.

In: Biochemical and Biophysical Research Communications, Vol. 125, No. 1, 30.11.1984, p. 90-96.

Research output: Contribution to journal › Article › peer-review

Gambari, R, del Senno, L, Piva, R, Barbieri, R, Amelotti, F, Bernardi, F, Marchetti, G, Citarella, F, Tripodi, M & Fantoni, A 1984, 'Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes', Biochemical and Biophysical Research Communications, vol. 125, no. 1, pp. 90-96. https://doi.org/10.1016/S0006-291X(84)80338-1

Gambari, Roberto ; del Senno, Laura ; Piva, Roberta ; Barbieri, Raffaella ; Amelotti, Francesca ; Bernardi, Francesco ; Marchetti, Giovanna ; Citarella, Franca ; Tripodi, Marco ; Fantoni, Antonio. / Human leukemia K562 cells : Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes. In: Biochemical and Biophysical Research Communications. 1984 ; Vol. 125, No. 1. pp. 90-96.

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