Abstract
We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level.
| Original language | English |
|---|---|
| Pages (from-to) | 90-96 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 125 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Nov 30 1984 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Human leukemia K562 cells : Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes. / Gambari, Roberto; del Senno, Laura; Piva, Roberta; Barbieri, Raffaella; Amelotti, Francesca; Bernardi, Francesco; Marchetti, Giovanna; Citarella, Franca; Tripodi, Marco; Fantoni, Antonio.
In: Biochemical and Biophysical Research Communications, Vol. 125, No. 1, 30.11.1984, p. 90-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human leukemia K562 cells
T2 - Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes
AU - Gambari, Roberto
AU - del Senno, Laura
AU - Piva, Roberta
AU - Barbieri, Raffaella
AU - Amelotti, Francesca
AU - Bernardi, Francesco
AU - Marchetti, Giovanna
AU - Citarella, Franca
AU - Tripodi, Marco
AU - Fantoni, Antonio
PY - 1984/11/30
Y1 - 1984/11/30
N2 - We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level.
AB - We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level.
UR - http://www.scopus.com/inward/record.url?scp=0021685217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021685217&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(84)80338-1
DO - 10.1016/S0006-291X(84)80338-1
M3 - Article
C2 - 6508811
AN - SCOPUS:0021685217
VL - 125
SP - 90
EP - 96
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -