Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes

Roberto Gambari, Laura del Senno, Roberta Piva, Raffaella Barbieri, Francesca Amelotti, Francesco Bernardi, Giovanna Marchetti, Franca Citarella, Marco Tripodi, Antonio Fantoni

Research output: Contribution to journalArticle

Abstract

We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume125
Issue number1
DOIs
Publication statusPublished - Nov 30 1984

Fingerprint

abl Genes
Hemin
Erythroid Cells
myc Genes
K562 Cells
Cell proliferation
Leukemia
Cells
Cell Proliferation
Cell Line
Hemoglobins
Genes
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Human leukemia K562 cells : Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes. / Gambari, Roberto; del Senno, Laura; Piva, Roberta; Barbieri, Raffaella; Amelotti, Francesca; Bernardi, Francesco; Marchetti, Giovanna; Citarella, Franca; Tripodi, Marco; Fantoni, Antonio.

In: Biochemical and Biophysical Research Communications, Vol. 125, No. 1, 30.11.1984, p. 90-96.

Research output: Contribution to journalArticle

Gambari, Roberto ; del Senno, Laura ; Piva, Roberta ; Barbieri, Raffaella ; Amelotti, Francesca ; Bernardi, Francesco ; Marchetti, Giovanna ; Citarella, Franca ; Tripodi, Marco ; Fantoni, Antonio. / Human leukemia K562 cells : Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes. In: Biochemical and Biophysical Research Communications. 1984 ; Vol. 125, No. 1. pp. 90-96.
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