Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes

Roberto Gambari, Laura del Senno, Roberta Piva, Raffaella Barbieri, Francesca Amelotti, Francesco Bernardi, Giovanna Marchetti, Franca Citarella, Marco Tripodi, Antonio Fantoni

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume125
Issue number1
DOIs
Publication statusPublished - Nov 30 1984

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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