Human leukocyte antigen class II genes and Helicobacter pylori infection: Does genotype overwhelm environmental exposure?

Antonio Russo, Giovanni Maconi, Claudia Lombardo, Daniela Settesoldi, Daniela Ferrari, Fernando Ravagnani, Salvatore Andreola, Paolo Pizzetti, Pasquale Spinelli, Lucio Bertario

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: We investigated associations between human leukocyte antigen class II genes, environmental exposures, and Helicobacter pylori infection. METHODS: Sixty-eight subjects with histologically confirmed H. pylori and intestinal metaplasia (cases) and 70 healthy subjects without H. pylori (controls) matched for age, sex, and year of birth were included in this study. All patients answered a detailed questionnaire designed to collect sociodemographic characteristics, smoking, alcohol drinking, and dietary habits. Human leukocyte antigen class II genes were typed with genomic DNA. The cytotoxins CagA and VacA were investigated with serology. Odds ratios and corresponding 95% confidence intervals were estimated from multivariate conditional logistic regression. Multiple correspondence analysis was used to represent the interrelationships of a multiple contingency table. RESULTS: Human leukocyte antigen DRB1, DQA1, and DQB1 genotypes were not significantly associated with H. pylori infection and intestinal metaplasia. No significant association with blood group or Lewis antigen system was found. However, multiple correspondence analysis clearly associated H. pylori with environmental exposure: the control group largely consumed olive oil, fresh fruits, and vegetables and histories of never or formerly smoking and the case group (those positive for H. pylori and metaplasia) largely consumed eggs, meat and butter and had histories of smoking cigarettes. CONCLUSIONS: These findings suggested that H. pylori infection is not influenced by a genetic compound and confirmed the relevance of environmental exposure.

Original languageEnglish
Pages (from-to)708-715
Number of pages8
JournalNutrition
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

MHC Class II Genes
Environmental Exposure
Helicobacter Infections
HLA Antigens
Helicobacter pylori
Genotype
Metaplasia
Smoking
Lewis Blood-Group System
Butter
Cytotoxins
Feeding Behavior
Serology
Blood Group Antigens
Alcohol Drinking
Vegetables
Meat
Eggs
Fruit
Healthy Volunteers

Keywords

  • Diet
  • Helicobacter pylori
  • HLA
  • Metaplasia
  • Smoking

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery
  • Medicine (miscellaneous)

Cite this

Human leukocyte antigen class II genes and Helicobacter pylori infection : Does genotype overwhelm environmental exposure? / Russo, Antonio; Maconi, Giovanni; Lombardo, Claudia; Settesoldi, Daniela; Ferrari, Daniela; Ravagnani, Fernando; Andreola, Salvatore; Pizzetti, Paolo; Spinelli, Pasquale; Bertario, Lucio.

In: Nutrition, Vol. 19, No. 9, 01.09.2003, p. 708-715.

Research output: Contribution to journalArticle

Russo, A, Maconi, G, Lombardo, C, Settesoldi, D, Ferrari, D, Ravagnani, F, Andreola, S, Pizzetti, P, Spinelli, P & Bertario, L 2003, 'Human leukocyte antigen class II genes and Helicobacter pylori infection: Does genotype overwhelm environmental exposure?', Nutrition, vol. 19, no. 9, pp. 708-715. https://doi.org/10.1016/S0899-9007(02)01034-1
Russo, Antonio ; Maconi, Giovanni ; Lombardo, Claudia ; Settesoldi, Daniela ; Ferrari, Daniela ; Ravagnani, Fernando ; Andreola, Salvatore ; Pizzetti, Paolo ; Spinelli, Pasquale ; Bertario, Lucio. / Human leukocyte antigen class II genes and Helicobacter pylori infection : Does genotype overwhelm environmental exposure?. In: Nutrition. 2003 ; Vol. 19, No. 9. pp. 708-715.
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