Abstract
The 11p15.5 chromosomal region (2.8Mb) is of particular interest as it encloses five genes (HRAS1, SIRT3, TH, INS and IGF2), the variability of which was found to be associated with life extension by association studies. Mostly important, the above genes are homologous of genes that modulate lifespan in model organisms. We scanned the area in four European sample groups for a total of 1321 centenarians and 1140 younger subjects, who shared with centenarians ethnicity and geographical origin, with a set of 239 SNPs. No significant results (P <0.05) have been found on the earlier associated loci (ie, TH, IGF2, INS and HRAS1), and this study could not confirm the earlier findings on each of those genes. A meta-analysis was carried out on the SIRT3 SNP data; a total number of 2461 samples were included, but no positive association was found except for one SNP having a significant effect (rs939915). The same meta-analysis approach has been applied to the other 229 markers, and six SNPs have been found significant for the frequent genotype (rs4073591, DEAF1-rs4073590, KRTAP5-6-rs11040489, rs4930001, TSPAN32-rs800140 and rs16928120). This experience, although unable to confirm the earlier findings of the literature, highlights all the common difficulties of such studies in human longevity. Despite the rather negative findings presented here, the results derived from unprecedented studies involving such a large number of centenarians should be disseminated, thus contributing to set up adequate strategies to disentangle complex and likely heterogeneous phenotypes.
| Original language | English |
|---|---|
| Pages (from-to) | 1515-1519 |
| Number of pages | 5 |
| Journal | European Journal of Human Genetics |
| Volume | 17 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2009 |
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ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
Human longevity and 11p15.5 : A study in 1321 centenarians. / Lescai, Francesco; Blanché, Helene; Nebel, Almut; Beekman, Marian; Sahbatou, Mourad; Flachsbart, Friederike; Slagboom, Eline; Schreiber, Stefan; Sorbi, Sandro; Passarino, Giuseppe; Franceschi, Claudio.
In: European Journal of Human Genetics, Vol. 17, No. 11, 2009, p. 1515-1519.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human longevity and 11p15.5
T2 - A study in 1321 centenarians
AU - Lescai, Francesco
AU - Blanché, Helene
AU - Nebel, Almut
AU - Beekman, Marian
AU - Sahbatou, Mourad
AU - Flachsbart, Friederike
AU - Slagboom, Eline
AU - Schreiber, Stefan
AU - Sorbi, Sandro
AU - Passarino, Giuseppe
AU - Franceschi, Claudio
PY - 2009
Y1 - 2009
N2 - The 11p15.5 chromosomal region (2.8Mb) is of particular interest as it encloses five genes (HRAS1, SIRT3, TH, INS and IGF2), the variability of which was found to be associated with life extension by association studies. Mostly important, the above genes are homologous of genes that modulate lifespan in model organisms. We scanned the area in four European sample groups for a total of 1321 centenarians and 1140 younger subjects, who shared with centenarians ethnicity and geographical origin, with a set of 239 SNPs. No significant results (P <0.05) have been found on the earlier associated loci (ie, TH, IGF2, INS and HRAS1), and this study could not confirm the earlier findings on each of those genes. A meta-analysis was carried out on the SIRT3 SNP data; a total number of 2461 samples were included, but no positive association was found except for one SNP having a significant effect (rs939915). The same meta-analysis approach has been applied to the other 229 markers, and six SNPs have been found significant for the frequent genotype (rs4073591, DEAF1-rs4073590, KRTAP5-6-rs11040489, rs4930001, TSPAN32-rs800140 and rs16928120). This experience, although unable to confirm the earlier findings of the literature, highlights all the common difficulties of such studies in human longevity. Despite the rather negative findings presented here, the results derived from unprecedented studies involving such a large number of centenarians should be disseminated, thus contributing to set up adequate strategies to disentangle complex and likely heterogeneous phenotypes.
AB - The 11p15.5 chromosomal region (2.8Mb) is of particular interest as it encloses five genes (HRAS1, SIRT3, TH, INS and IGF2), the variability of which was found to be associated with life extension by association studies. Mostly important, the above genes are homologous of genes that modulate lifespan in model organisms. We scanned the area in four European sample groups for a total of 1321 centenarians and 1140 younger subjects, who shared with centenarians ethnicity and geographical origin, with a set of 239 SNPs. No significant results (P <0.05) have been found on the earlier associated loci (ie, TH, IGF2, INS and HRAS1), and this study could not confirm the earlier findings on each of those genes. A meta-analysis was carried out on the SIRT3 SNP data; a total number of 2461 samples were included, but no positive association was found except for one SNP having a significant effect (rs939915). The same meta-analysis approach has been applied to the other 229 markers, and six SNPs have been found significant for the frequent genotype (rs4073591, DEAF1-rs4073590, KRTAP5-6-rs11040489, rs4930001, TSPAN32-rs800140 and rs16928120). This experience, although unable to confirm the earlier findings of the literature, highlights all the common difficulties of such studies in human longevity. Despite the rather negative findings presented here, the results derived from unprecedented studies involving such a large number of centenarians should be disseminated, thus contributing to set up adequate strategies to disentangle complex and likely heterogeneous phenotypes.
UR - http://www.scopus.com/inward/record.url?scp=70350365059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350365059&partnerID=8YFLogxK
U2 - 10.1038/ejhg.2009.54
DO - 10.1038/ejhg.2009.54
M3 - Article
C2 - 19367319
AN - SCOPUS:70350365059
VL - 17
SP - 1515
EP - 1519
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
SN - 1018-4813
IS - 11
ER -