Human mesenchymal stem cells and biomaterials interaction: A promising synergy to improve spine fusion

G. Barbanti Brodano, E. Mazzoni, M. Tognon, C. Griffoni, M. Manfrini

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: Spine fusion is the gold standard treatment in degenerative and traumatic spine diseases. The bone regenerative medicine needs (i) in vitro functionally active osteoblasts, and/or (ii) the in vivo induction of the tissue. The bone tissue engineering seems to be a very promising approach for the effectiveness of orthopedic surgical procedures, clinical applications are often hampered by the limited availability of bone allograft or substitutes. New biomaterials have been recently developed for the orthopedic applications. The main characteristics of these scaffolds are the ability to induce the bone tissue formation by generating an appropriate environment for (i) the cell growth and (ii) recruiting precursor bone cells for the proliferation and differentiation. A new prototype of bio-materials known as " bioceramics" may own these features. Bioceramics are bone substitutes mainly composed of calcium and phosphate complex salt derivatives. Methods: In this study, the characteristics bioceramics bone substitutes have been tested with human mesenchy-mal stem cells obtained from the bone marrow of adult orthopedic patients. Results: These cellular models can be employed to characterize in vitro the behavior of different biomaterials, which are used as bone void fillers or three-dimensional scaffolds. Conclusions: Human mesenchymal stem cells in combination with biomaterials seem to be good alternative to the autologous or allogenic bone fusion in spine surgery. The cellular model used in our study is a useful tool for investigating cytocompatibility and biological features of HA-derived scaffolds.

Original languageEnglish
JournalEuropean Spine Journal
Volume21
Issue numberSUPPL. 1
DOIs
Publication statusPublished - May 2012

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Biocompatible Materials
Mesenchymal Stromal Cells
Cell Communication
Spine
Bone and Bones
Bone Substitutes
Orthopedics
Orthopedic Procedures
Aptitude
Regenerative Medicine
Tissue Engineering
Osteoblasts
Osteogenesis
Allografts
Cell Differentiation
Stem Cells
Salts
Bone Marrow
Cell Proliferation
Growth

Keywords

  • Bone
  • Proliferation
  • Scaffold
  • Spine fusion
  • Stem cell

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Human mesenchymal stem cells and biomaterials interaction : A promising synergy to improve spine fusion. / Barbanti Brodano, G.; Mazzoni, E.; Tognon, M.; Griffoni, C.; Manfrini, M.

In: European Spine Journal, Vol. 21, No. SUPPL. 1, 05.2012.

Research output: Contribution to journalArticle

Barbanti Brodano, G. ; Mazzoni, E. ; Tognon, M. ; Griffoni, C. ; Manfrini, M. / Human mesenchymal stem cells and biomaterials interaction : A promising synergy to improve spine fusion. In: European Spine Journal. 2012 ; Vol. 21, No. SUPPL. 1.
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