TY - JOUR
T1 - Human milk and formulae
T2 - Neurotrophic and new biological factors
AU - Serpero, Laura D.
AU - Frigiola, Alessandro
AU - Gazzolo, Diego
PY - 2012/3
Y1 - 2012/3
N2 - Mother milk is widely accepted to be a unique product believed to contain biological factors involved in the regulation of newborn optimal growth including brain when compared to milk-formula milks. In this setting, there is growing evidence that in milk-formula neuro-oxidative stress biomarkers, neurotrophic proteins and calcium binding proteins, known to be involved in a cascade of events leading to brain, cardiac and vascular development/damage, are to date lacking or at a lower concentration than breast milk.Therefore, this review is aimed at offering additional insights to the role in human milk of some selected biomarkers such as: i) neurotrophic factors such as Activin A; ii) Calcium binding protein such as S100B and, iii) heat shock protein known to be involved in oxidative stress response (namely hemeoxygenase-1, HO-1 or Heat shock Protein 32, HSP32).
AB - Mother milk is widely accepted to be a unique product believed to contain biological factors involved in the regulation of newborn optimal growth including brain when compared to milk-formula milks. In this setting, there is growing evidence that in milk-formula neuro-oxidative stress biomarkers, neurotrophic proteins and calcium binding proteins, known to be involved in a cascade of events leading to brain, cardiac and vascular development/damage, are to date lacking or at a lower concentration than breast milk.Therefore, this review is aimed at offering additional insights to the role in human milk of some selected biomarkers such as: i) neurotrophic factors such as Activin A; ii) Calcium binding protein such as S100B and, iii) heat shock protein known to be involved in oxidative stress response (namely hemeoxygenase-1, HO-1 or Heat shock Protein 32, HSP32).
KW - Activin A
KW - Brain development
KW - Feeding
KW - HO-1
KW - Milk
KW - Milk-formulae
KW - Newborn
KW - S100B
UR - http://www.scopus.com/inward/record.url?scp=84858080865&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858080865&partnerID=8YFLogxK
U2 - 10.1016/j.earlhumdev.2011.12.021
DO - 10.1016/j.earlhumdev.2011.12.021
M3 - Article
C2 - 22261291
AN - SCOPUS:84858080865
VL - 88
JO - Early Human Development
JF - Early Human Development
SN - 0378-3782
IS - SUPPL. 1
ER -