Human monoclonal antibody against a gag-coded protein of human immunodeficiency virus produced by a stable EBV-transformed cell clone

A. Amadori, V. Criminale, M. L. Calabro, L. Tessarollo, E. Francavilla, L. Chieco-Bianchi

Research output: Contribution to journalArticle

Abstract

An EBV-transformed lymphoblastoid B cell clone (A12) derived from peripheral blood lymphocytes of an HIV-1-infected individual is described. The immunoglobulin isotype produced by this clone was IgM, and Southern blot analysis of immunoglobulin gene rearrangement showed a monoclonal pattern. The A12 monoclonal antibody was specific for the p24 product of the HIV-1 gag gene. This clone is now in continuous culture for more than 8 months and no changes in its biologic properties have been observed.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume5
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology
  • Virology

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