Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor

Silvano Sozzani, Daniela Longoni, Raffaella Bonecchi, Walter Luini, Laura Bersani, Giovanna D'Amico, Alessandro Borsatti, Federico Bussolino, Paola Allavena, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DC) are a heterogeneous population of specialized antigen presenting cells that exhibit complex trafficking properties. DC differentiated in vitro from both peripheral monocytes and CD34+ cells expressed mRNA for platelet activating factor (PAF) receptor. Expression of PAF receptor was increased by TNFα, a prototypic inflammatory cytokine that induces differentiation and in vivo mobilization of DC. PAP induced in vitro directional migration of DC obtained from both precursor cells through its specific receptor. Since DC are highly motile cells, protein chemoattractants as well as bioactive phospholipids are likely to contribute to tissue localization of DC, in vivo.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalFEBS Letters
Volume418
Issue number1-2
DOIs
Publication statusPublished - Nov 24 1997

Keywords

  • Dendritic cell
  • Platelet activating factor receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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