Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells

M. Nizzardo, C. Simone, M. Falcone, F. Locatelli, G. Riboldi, G. P. Comi, S. Corti

Research output: Contribution to journalArticlepeer-review

Abstract

Motor neuron diseases (MNDs) are a group of neurological disorders that selectively affect motor neurons. There are currently no cures or efficacious treatments for these diseases. In recent years, significant developments in stem cell research have been applied to MNDs, particularly regarding neuroprotection and cell replacement. However, a consistent source of motor neurons for cell replacement is required. Human embryonic stem cells (hESCs) could provide an inexhaustible supply of differentiated cell types, including motor neurons that could be used for MND therapies. Recently, it has been demonstrated that induced pluripotent stem (iPS) cells may serve as an alternative source of motor neurons, since they share ES characteristics, self-renewal, and the potential to differentiate into any somatic cell type. In this review, we discuss several reproducible methods by which hESCs or iPS cells are efficiently isolated and differentiated into functional motor neurons, and possible clinical applications.

Original languageEnglish
Pages (from-to)3837-3847
Number of pages11
JournalCellular and Molecular Life Sciences
Volume67
Issue number22
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Embryonic stem cell
  • Induced pluripotent stem cell
  • Motor neuron
  • Motor neuron diseases
  • Protocol

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

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