Human myeloma cells express the CD38 ligand CD31

Antonella Vallario, Marco Chilosi, Fausto Adami, Licia Montagna, Silvia Deaglio, Fabio Malavasi, Federico Caligaris-Cappio

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple myeloma (MM) plasma cells (PC) are CD38+. A ligand for CD38 is the adhesion molecule CD31. By flow cytometry and immunocytochemistry we have investigated whether malignant PC co-express CD38 and CD31. All 68 patients studied were CD38+. 14/14 monoclonal gammopathies of undetermined significance (MGUS) and 39/39 plasmacytic MM patients co-expressed CD38 and CD31 at high density. Only 1/11 plasmablastic MM and 1/4 plasma cell leukaemias (PCL) expressed CD31. These data indicated that PC malignancies co-expressed high levels of both CD38 and its ligand CD31, with the exception of plasmablastic MM and PCL.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalBritish Journal of Haematology
Volume105
Issue number2
Publication statusPublished - 1999

Keywords

  • CD31
  • CD38
  • Multiple myeloma
  • Plasma cells
  • Receptors

ASJC Scopus subject areas

  • Hematology

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