Human natural killer cells

Molecular mechanisms controlling NK cell activation and tumor cell lysis

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Natural killer cells represent a highly specialized lymphoid population with a potent cytolytic activity against virus-infected or tumor cells. Their function is regulated by a series of inhibiting or activating signals. The mechanisms by which NK cells kill susceptible target cells was thought to be elucidated after the discovery of inhibitory receptors specific for MHC-class I molecules: NK cells would kill those target cells that lack MHC-class I molecules. However, the actual scenario revealed more complex with the discovery of activating receptors and their ligands. Thus, in certain pathological conditions, corticosteroid treatment or exposure to TGFβ, NK cells may under-express activating receptors. In addition, target cells may lack ligands for activating receptors and thus fail to activate NK cells upon cell-to-cell contact. This clearly implies that activation of NK cells and of their potent effector mechanism are under the control of different checkpoints.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalImmunology Letters
Volume100
Issue number1
DOIs
Publication statusPublished - Aug 15 2005

Fingerprint

Natural Killer Cells
Neoplasms
Ligands
Adrenal Cortex Hormones
Viruses
Population

Keywords

  • Activating NK receptors
  • Cellular ligands
  • Inhibitory NK receptors
  • Innate immunity
  • NK cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

@article{955acac83ca04fe28fe46345364e2b0e,
title = "Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis",
abstract = "Natural killer cells represent a highly specialized lymphoid population with a potent cytolytic activity against virus-infected or tumor cells. Their function is regulated by a series of inhibiting or activating signals. The mechanisms by which NK cells kill susceptible target cells was thought to be elucidated after the discovery of inhibitory receptors specific for MHC-class I molecules: NK cells would kill those target cells that lack MHC-class I molecules. However, the actual scenario revealed more complex with the discovery of activating receptors and their ligands. Thus, in certain pathological conditions, corticosteroid treatment or exposure to TGFβ, NK cells may under-express activating receptors. In addition, target cells may lack ligands for activating receptors and thus fail to activate NK cells upon cell-to-cell contact. This clearly implies that activation of NK cells and of their potent effector mechanism are under the control of different checkpoints.",
keywords = "Activating NK receptors, Cellular ligands, Inhibitory NK receptors, Innate immunity, NK cells",
author = "Lorenzo Moretta and Cristina Bottino and Daniela Pende and Massimo Vitale and Mingari, {Maria Cristina} and Alessandro Moretta",
year = "2005",
month = "8",
day = "15",
doi = "10.1016/j.imlet.2005.07.004",
language = "English",
volume = "100",
pages = "7--13",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Human natural killer cells

T2 - Molecular mechanisms controlling NK cell activation and tumor cell lysis

AU - Moretta, Lorenzo

AU - Bottino, Cristina

AU - Pende, Daniela

AU - Vitale, Massimo

AU - Mingari, Maria Cristina

AU - Moretta, Alessandro

PY - 2005/8/15

Y1 - 2005/8/15

N2 - Natural killer cells represent a highly specialized lymphoid population with a potent cytolytic activity against virus-infected or tumor cells. Their function is regulated by a series of inhibiting or activating signals. The mechanisms by which NK cells kill susceptible target cells was thought to be elucidated after the discovery of inhibitory receptors specific for MHC-class I molecules: NK cells would kill those target cells that lack MHC-class I molecules. However, the actual scenario revealed more complex with the discovery of activating receptors and their ligands. Thus, in certain pathological conditions, corticosteroid treatment or exposure to TGFβ, NK cells may under-express activating receptors. In addition, target cells may lack ligands for activating receptors and thus fail to activate NK cells upon cell-to-cell contact. This clearly implies that activation of NK cells and of their potent effector mechanism are under the control of different checkpoints.

AB - Natural killer cells represent a highly specialized lymphoid population with a potent cytolytic activity against virus-infected or tumor cells. Their function is regulated by a series of inhibiting or activating signals. The mechanisms by which NK cells kill susceptible target cells was thought to be elucidated after the discovery of inhibitory receptors specific for MHC-class I molecules: NK cells would kill those target cells that lack MHC-class I molecules. However, the actual scenario revealed more complex with the discovery of activating receptors and their ligands. Thus, in certain pathological conditions, corticosteroid treatment or exposure to TGFβ, NK cells may under-express activating receptors. In addition, target cells may lack ligands for activating receptors and thus fail to activate NK cells upon cell-to-cell contact. This clearly implies that activation of NK cells and of their potent effector mechanism are under the control of different checkpoints.

KW - Activating NK receptors

KW - Cellular ligands

KW - Inhibitory NK receptors

KW - Innate immunity

KW - NK cells

UR - http://www.scopus.com/inward/record.url?scp=24344505476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24344505476&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2005.07.004

DO - 10.1016/j.imlet.2005.07.004

M3 - Article

VL - 100

SP - 7

EP - 13

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

IS - 1

ER -