Human natural killer (NK) alloreactivity and its association with the major histocompatibility complex: Ancestral haplotypes encode particular NK- defined haplotypes

F. T. Christiansen, C. S. Witt, E. Ciccone, D. Townend, D. Pende, D. Viale, L. J. Abraham, R. L. Dawkins, L. Moretta

Research output: Contribution to journalArticlepeer-review

Abstract

As ancestral haplotypes of the major histocompatibility complex (MHC) appear to define identical MHC haplotypes in unrelated individuals, unrelated individuals sharing the same ancestral haplotype should also share the same NK-defined allospecificities that have recently been shown to map to the human MHC. To test this prediction, multiple cell lines from unrelated individuals sharing the same ancestral haplotypes were tested for the NK- defined allospecificities. It was found that cells sharing the same ancestral haplotypes do have the same NK-defined specificities. Furthermore, the NK- defined phenotype of cells that possess two different ancestral haplotypes can be predicted from the NK-defined phenotypes of unrelated cells that are homozygous for the ancestral haplotypes concerned. Although the group 1 and 2 NK-defined allospecificities can be explained to some extent by HLA-C alleles, evidence is presented that additional genes may modify the phenotype conferred by HLA-C.

Original languageEnglish
Pages (from-to)1033-1039
Number of pages7
JournalJournal of Experimental Medicine
Volume178
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Immunology

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