Human neural stem cells express extra-neural markers

Eugenio A. Parati, Alessandra Bez, Dario Ponti, Ugo de Grazia, Elena Corsini, Lidia Cova, Simona Sala, Augusto Colombo, Giulio Alessandri, Stefano F. Pagano

Research output: Contribution to journalArticlepeer-review

Abstract

Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalBrain Research
Volume925
Issue number2
DOIs
Publication statusPublished - Jan 25 2002

Keywords

  • Embryonic development
  • Endothelial receptors
  • Human CNS stem cells
  • Multipotent precursors

ASJC Scopus subject areas

  • Neuroscience(all)

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