Abstract
Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.
| Original language | English |
|---|---|
| Pages (from-to) | 213-221 |
| Number of pages | 9 |
| Journal | Brain Research |
| Volume | 925 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 25 2002 |
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Keywords
- Embryonic development
- Endothelial receptors
- Human CNS stem cells
- Multipotent precursors
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Human neural stem cells express extra-neural markers. / Parati, Eugenio A.; Bez, Alessandra; Ponti, Dario; de Grazia, Ugo; Corsini, Elena; Cova, Lidia; Sala, Simona; Colombo, Augusto; Alessandri, Giulio; Pagano, Stefano F.
In: Brain Research, Vol. 925, No. 2, 25.01.2002, p. 213-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human neural stem cells express extra-neural markers
AU - Parati, Eugenio A.
AU - Bez, Alessandra
AU - Ponti, Dario
AU - de Grazia, Ugo
AU - Corsini, Elena
AU - Cova, Lidia
AU - Sala, Simona
AU - Colombo, Augusto
AU - Alessandri, Giulio
AU - Pagano, Stefano F.
PY - 2002/1/25
Y1 - 2002/1/25
N2 - Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.
AB - Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.
KW - Embryonic development
KW - Endothelial receptors
KW - Human CNS stem cells
KW - Multipotent precursors
UR - http://www.scopus.com/inward/record.url?scp=0037169241&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037169241&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(01)03291-7
DO - 10.1016/S0006-8993(01)03291-7
M3 - Article
C2 - 11792370
AN - SCOPUS:0037169241
VL - 925
SP - 213
EP - 221
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -