Human neural stem cells express extra-neural markers

Eugenio A. Parati; Alessandra Bez; Dario Ponti; Ugo de Grazia; Elena Corsini; Lidia Cova; Simona Sala; Augusto Colombo; Giulio Alessandri; Stefano F. Pagano

doi:10.1016/S0006-8993(01)03291-7

Human neural stem cells express extra-neural markers

Eugenio A. Parati, Alessandra Bez, Dario Ponti, Ugo de Grazia, Elena Corsini, Lidia Cova, Simona Sala, Augusto Colombo, Giulio Alessandri, Stefano F. Pagano

Research output: Contribution to journal › Article › peer-review

Abstract

Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.

Original language	English
Pages (from-to)	213-221
Number of pages	9
Journal	Brain Research
Volume	925
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)03291-7
Publication status	Published - Jan 25 2002

Keywords

Embryonic development
Endothelial receptors
Human CNS stem cells
Multipotent precursors

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/S0006-8993(01)03291-7

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abstract = "Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.",

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AU - Parati, Eugenio A.

AU - Bez, Alessandra

AU - Ponti, Dario

AU - de Grazia, Ugo

AU - Corsini, Elena

AU - Cova, Lidia

AU - Sala, Simona

AU - Colombo, Augusto

AU - Alessandri, Giulio

AU - Pagano, Stefano F.

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AB - Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.

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