Human neuronal cells in culture: from concepts to basic methodology.

V. Silani, A. Pizzuti, M. F. Donato, A. Falini, R. Bassani, O. Strada, R. I. Causarano, D. Mariani, R. M. Villani, G. Scarlato

Research output: Contribution to journalArticlepeer-review


The paper reviews some conceptual and methodological aspects of the tissue culture models which, during the past three decades, demonstrated a remarkable mimicry of many important structures and functions of the mammalian Central Nervous System (CNS) and related peripheral sensory and motor elements. Emphasis is placed on an original human neuronal tissue culture model obtained from selective CNS areas. The different cell types were identified and the neurotrophic interactions preliminary characterized. Neuropathological findings suggest hypothesis that can be fully tested using in vitro human models of affected cerebral specific areas.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalBollettino dell'Istituto Sieroterapico Milanese
Issue number1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology


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