TY - JOUR
T1 - Human NK cell receptors/markers
T2 - A tool to analyze NK cell development, subsets and function
AU - Montaldo, Elisa
AU - Zotto, Genny Del
AU - Chiesa, Mariella Della
AU - Mingari, Maria Cristina
AU - Moretta, Alessandro
AU - Maria, Andrea De
AU - Moretta, Lorenzo
PY - 2013/8
Y1 - 2013/8
N2 - Natural killer (NK) cells are important components of the innate immunity and play a key role in host defense by virtue of their ability to release cytokines and to mediate cytolytic activity against tumor cells and virus-infected cells. NK cells were first described more than 30 years ago on the basis of their peculiar functional capabilities. Subsequently, thanks to the production of a variety of monoclonal antibodies, it became possible to identify surface receptors and markers expressed by NK cells as well as to characterize their functional properties. Here, we provide a brief historical overview about the discovery of human NK cell receptors and we delineate the main phenotypic features of differentiating and mature NK cells in healthy donors as well as their alterations in certain pathologic conditions.
AB - Natural killer (NK) cells are important components of the innate immunity and play a key role in host defense by virtue of their ability to release cytokines and to mediate cytolytic activity against tumor cells and virus-infected cells. NK cells were first described more than 30 years ago on the basis of their peculiar functional capabilities. Subsequently, thanks to the production of a variety of monoclonal antibodies, it became possible to identify surface receptors and markers expressed by NK cells as well as to characterize their functional properties. Here, we provide a brief historical overview about the discovery of human NK cell receptors and we delineate the main phenotypic features of differentiating and mature NK cells in healthy donors as well as their alterations in certain pathologic conditions.
KW - Cytolytic activity
KW - Haploidentical hematopoietic stem cell transplantation
KW - Natural killer cell cytokine production
KW - Natural killer cell differentiation
KW - Natural killer cell receptors
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U2 - 10.1002/cyto.a.22302
DO - 10.1002/cyto.a.22302
M3 - Article
C2 - 23650273
AN - SCOPUS:84881029114
VL - 83
SP - 702
EP - 713
JO - Cytometry. Part A : the journal of the International Society for Analytical Cytology
JF - Cytometry. Part A : the journal of the International Society for Analytical Cytology
SN - 1552-4922
IS - 8
ER -