Human normal CD5+ B lymphocytes can be induced to differentiate to CD5- B lymphocytes with germinal center cell features

F. Caligaris-Cappio, M. Riva, L. Tesio, M. Schena, G. Gaidano, L. Bergui

Research output: Contribution to journalArticle

Abstract

A significant proportion of cord blood CD5+ B cells express the activation molecules CD23, CD25, and transferrin receptor; react with the cell-cycle-associated monoclonal antibody (MoAb) Ki67; can be induced to enter the S phase of cell cycle by interleukin-2 (IL-2), IL-4, or low-molecular-weight B-cell growth factor (lmw-BCGF) and, exposed to IL-1 and IL-2, acquire the features (sIgD-, CD5-, CD10+, CD38+) of B blasts proliferating in the germinal centers of secondary follicles. These findings indicate that CD5+ B cells are preactivated and, in the proper microenvironment, may give rise to CD5-B cells.

Original languageEnglish
Pages (from-to)1259-1263
Number of pages5
JournalBlood
Volume73
Issue number5
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Hematology

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    Caligaris-Cappio, F., Riva, M., Tesio, L., Schena, M., Gaidano, G., & Bergui, L. (1989). Human normal CD5+ B lymphocytes can be induced to differentiate to CD5- B lymphocytes with germinal center cell features. Blood, 73(5), 1259-1263.