Human osteosarcoma cell susceptibility to natural killer cell lysis depends on CD54 and increases after TNFα incubation

Erminia Mariani, Andrea Tarozzi, Alessandra Meneghetti, Luca Cattini, Andrea Facchini

Research output: Contribution to journalArticlepeer-review

Abstract

Osteosarcoma cell lines vary widely in their susceptibility to natural killer (NK) cell lysis in vitro although it is still unclear why this occurs. In this study we investigated the expression of some cell adhesion molecules on osteosarcomas to determine which of these can modify the susceptibility to NK lysis and we also attempted to modulate tile cytolytic susceptibility of these targets with TNFα. We found that osteosarcoma lysis induced by NK cells correlates with different expression of the CD54 adhesion molecule on osteosarcomas and the increased susceptibility after TNFα treatment mostly depends on the expression of CD54 molecules on target cells.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalFEBS Letters
Volume406
Issue number1-2
DOIs
Publication statusPublished - Apr 7 1997

Keywords

  • CD54
  • NK cell lysis
  • Osteosarcoma cell line
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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