Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma

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Abstract

P63, and in particular the most expressed ΔNp63α isoform, seems to have a critical role in the outcome of head and neck cancer. Many studies have been conducted to assess the possible use of p63 as a prognostic marker in squamous cell carcinoma cancers, but the results are still not well-defined. Moreover, a clear relationship between the expression of ΔNp63α and the presence of high-risk HPV E6 and E7 oncoproteins has been delineated. Here we describe how ΔNp63α is mostly expressed in HPV-positive compared to HPV-negative head and neck cancer cell lines, with a very good correlation between ΔNp63α mRNA and protein levels.

Original languageEnglish
Article number143
JournalFrontiers in cellular and infection microbiology
Volume10
DOIs
Publication statusPublished - Apr 8 2020

Keywords

  • head and neck cancer
  • head and neck carcinoma
  • HPV
  • HPV16
  • p63

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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