Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults

Veronica Rainone, Vania Giacomet, Francesca Penagini, Valentina Fabiano, Francesca Calascibetta, Chiara Mameli, Stefania Pisanelli, Gian Vincenzo Zuccotti, Mario Clerici, Daria Trabattoni

Research output: Contribution to journalArticle

Abstract

The ability of a quadrivalent human papillomavirus (HPV)-16/18/6/11 virus-like particles vaccine (Gardasil) to elicit HPV-specific cell-mediated immune responses was evaluated in antiretroviral therapy (ART)-treated HIV-infected young adults. Results showed that, after three doses of vaccine, central memory and effector memory CD4+ and CD8+ T lymphocytes, aswell as HPV-specific interleukin (IL)2R/CD4+, interferon-gamma (IFN-γ+)/ CD4+, IFN-γ+/CD8+ and tumour necrosis factoralpha (TNF-α)R/CD8+ T lymphocytes and Perforin and Granzyme B secreting CD8+ T lymphocytes were significantly increased. Notably, results obtained in HIV-infected patients were comparable to those seen in HIV-uninfected agematched healthy controls.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalAIDS (London, England)
Volume29
Issue number6
DOIs
Publication statusPublished - Mar 27 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases
  • Medicine(all)

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    Rainone, V., Giacomet, V., Penagini, F., Fabiano, V., Calascibetta, F., Mameli, C., Pisanelli, S., Zuccotti, G. V., Clerici, M., & Trabattoni, D. (2015). Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults. AIDS (London, England), 29(6), 739-743. https://doi.org/10.1097/QAD.0000000000000597