Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults

Veronica Rainone, Vania Giacomet, Francesca Penagini, Valentina Fabiano, Francesca Calascibetta, Chiara Mameli, Stefania Pisanelli, Gian Vincenzo Zuccotti, Mario Clerici, Daria Trabattoni

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The ability of a quadrivalent human papillomavirus (HPV)-16/18/6/11 virus-like particles vaccine (Gardasil) to elicit HPV-specific cell-mediated immune responses was evaluated in antiretroviral therapy (ART)-treated HIV-infected young adults. Results showed that, after three doses of vaccine, central memory and effector memory CD4+ and CD8+ T lymphocytes, aswell as HPV-specific interleukin (IL)2R/CD4+, interferon-gamma (IFN-γ+)/ CD4+, IFN-γ+/CD8+ and tumour necrosis factoralpha (TNF-α)R/CD8+ T lymphocytes and Perforin and Granzyme B secreting CD8+ T lymphocytes were significantly increased. Notably, results obtained in HIV-infected patients were comparable to those seen in HIV-uninfected agematched healthy controls.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalAIDS (London, England)
Volume29
Issue number6
DOIs
Publication statusPublished - Mar 27 2015

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Papillomaviridae
Young Adult
Vaccination
HIV
T-Lymphocytes
Virus-Like Particle Vaccines
Human papillomavirus 18
Human papillomavirus 16
Interleukins
Interferon-gamma
Necrosis
Vaccines
Neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases
  • Medicine(all)

Cite this

Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults. / Rainone, Veronica; Giacomet, Vania; Penagini, Francesca; Fabiano, Valentina; Calascibetta, Francesca; Mameli, Chiara; Pisanelli, Stefania; Zuccotti, Gian Vincenzo; Clerici, Mario; Trabattoni, Daria.

In: AIDS (London, England), Vol. 29, No. 6, 27.03.2015, p. 739-743.

Research output: Contribution to journalArticle

Rainone, V, Giacomet, V, Penagini, F, Fabiano, V, Calascibetta, F, Mameli, C, Pisanelli, S, Zuccotti, GV, Clerici, M & Trabattoni, D 2015, 'Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults', AIDS (London, England), vol. 29, no. 6, pp. 739-743. https://doi.org/10.1097/QAD.0000000000000597
Rainone, Veronica ; Giacomet, Vania ; Penagini, Francesca ; Fabiano, Valentina ; Calascibetta, Francesca ; Mameli, Chiara ; Pisanelli, Stefania ; Zuccotti, Gian Vincenzo ; Clerici, Mario ; Trabattoni, Daria. / Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults. In: AIDS (London, England). 2015 ; Vol. 29, No. 6. pp. 739-743.
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