Human papillomavirus 16 E6 antibodies in individuals without diagnosed cancer: A pooled analysis

Krystle A. Lang Kuhs, Devasena Anantharaman, Tim Waterboer, Mattias Johansson, Paul Brennan, Angelika Michel, Martina Willhauck-Fleckenstein, Mark P. Purdue, Ivana Holcátová, Wolfgang Ahrens, Pagona Lagiou, Jerry Polesel, Lorenzo Simonato, Franco Merletti, Claire M. Healy, Kristina Kjaerheim, David I. Conway, Tatiana V. Macfarlane, Peter Thomson, Xavier CastellsaguéAriana Znaor, Amanda Black, Wen Yi Huang, Vittorio Krogh, Antonia Trichopoulou, H. B A S Bueno-De-Mesquita, Françoise Clavel-Chapelon, Elisabete Weiderpass, Johanna Ekström, Elio Riboli, Anne Tjønneland, María José Sánchez, Ruth C. Travis, Allan Hildesheim, Michael Pawlita, Aimée R. Kreimer

Research output: Contribution to journalArticlepeer-review


Background: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted. Methods: A total of 4,666 controls were pooled from several studies of cancer and HPV seropositivity, all tested within the same laboratory. HPV16 E6 seropositive controls were classified as having (i) moderate [mean fluorescent intensity (MFI) ≥ 484 and

Original languageEnglish
Pages (from-to)683-689
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Issue number4
Publication statusPublished - Apr 1 2015

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


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