Human papillomavirus 16 E6 antibodies in individuals without diagnosed cancer: A pooled analysis

Krystle A. Lang Kuhs; Devasena Anantharaman; Tim Waterboer; Mattias Johansson; Paul Brennan; Angelika Michel; Martina Willhauck-Fleckenstein; Mark P. Purdue; Ivana Holcátová; Wolfgang Ahrens; Pagona Lagiou; Jerry Polesel; Lorenzo Simonato; Franco Merletti; Claire M. Healy; Kristina Kjaerheim; David I. Conway; Tatiana V. Macfarlane; Peter Thomson; Xavier Castellsagué; Ariana Znaor; Amanda Black; Wen Yi Huang; Vittorio Krogh; Antonia Trichopoulou; H. B A S Bueno-De-Mesquita; Françoise Clavel-Chapelon; Elisabete Weiderpass; Johanna Ekström; Elio Riboli; Anne Tjønneland; María José Sánchez; Ruth C. Travis; Allan Hildesheim; Michael Pawlita; Aimée R. Kreimer

doi:10.1158/1055-9965.EPI-14-1217

Human papillomavirus 16 E6 antibodies in individuals without diagnosed cancer: A pooled analysis

Krystle A. Lang Kuhs, Devasena Anantharaman, Tim Waterboer, Mattias Johansson, Paul Brennan, Angelika Michel, Martina Willhauck-Fleckenstein, Mark P. Purdue, Ivana Holcátová, Wolfgang Ahrens, Pagona Lagiou, Jerry Polesel, Lorenzo Simonato, Franco Merletti, Claire M. Healy, Kristina Kjaerheim, David I. Conway, Tatiana V. Macfarlane, Peter Thomson, Xavier CastellsaguéAriana Znaor, Amanda Black, Wen Yi Huang, Vittorio Krogh, Antonia Trichopoulou, H. B A S Bueno-De-Mesquita, Françoise Clavel-Chapelon, Elisabete Weiderpass, Johanna Ekström, Elio Riboli, Anne Tjønneland, María José Sánchez, Ruth C. Travis, Allan Hildesheim, Michael Pawlita, Aimée R. Kreimer

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted. Methods: A total of 4,666 controls were pooled from several studies of cancer and HPV seropositivity, all tested within the same laboratory. HPV16 E6 seropositive controls were classified as having (i) moderate [mean fluorescent intensity (MFI) ≥ 484 and

Original language	English
Pages (from-to)	683-689
Number of pages	7
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	24
Issue number	4
DOIs	https://doi.org/10.1158/1055-9965.EPI-14-1217
Publication status	Published - Apr 1 2015

ASJC Scopus subject areas

Epidemiology
Oncology

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10.1158/1055-9965.EPI-14-1217

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Lang Kuhs, K. A., Anantharaman, D., Waterboer, T., Johansson, M., Brennan, P., Michel, A., Willhauck-Fleckenstein, M., Purdue, M. P., Holcátová, I., Ahrens, W., Lagiou, P., Polesel, J., Simonato, L., Merletti, F., Healy, C. M., Kjaerheim, K., Conway, D. I., Macfarlane, T. V., Thomson, P., ... Kreimer, A. R. (2015). Human papillomavirus 16 E6 antibodies in individuals without diagnosed cancer: A pooled analysis. Cancer Epidemiology Biomarkers and Prevention, 24(4), 683-689. https://doi.org/10.1158/1055-9965.EPI-14-1217

Lang Kuhs, KA, Anantharaman, D, Waterboer, T, Johansson, M, Brennan, P, Michel, A, Willhauck-Fleckenstein, M, Purdue, MP, Holcátová, I, Ahrens, W, Lagiou, P, Polesel, J, Simonato, L, Merletti, F, Healy, CM, Kjaerheim, K, Conway, DI, Macfarlane, TV, Thomson, P, Castellsagué, X, Znaor, A, Black, A, Huang, WY, Krogh, V, Trichopoulou, A, Bueno-De-Mesquita, HBAS, Clavel-Chapelon, F, Weiderpass, E, Ekström, J, Riboli, E, Tjønneland, A, Sánchez, MJ, Travis, RC, Hildesheim, A, Pawlita, M & Kreimer, AR 2015, 'Human papillomavirus 16 E6 antibodies in individuals without diagnosed cancer: A pooled analysis', Cancer Epidemiology Biomarkers and Prevention, vol. 24, no. 4, pp. 683-689. https://doi.org/10.1158/1055-9965.EPI-14-1217

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abstract = "Background: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted. Methods: A total of 4,666 controls were pooled from several studies of cancer and HPV seropositivity, all tested within the same laboratory. HPV16 E6 seropositive controls were classified as having (i) moderate [mean fluorescent intensity (MFI) ≥ 484 and ",

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T2 - A pooled analysis

AU - Lang Kuhs, Krystle A.

AU - Anantharaman, Devasena

AU - Waterboer, Tim

AU - Johansson, Mattias

AU - Brennan, Paul

AU - Michel, Angelika

AU - Willhauck-Fleckenstein, Martina

AU - Purdue, Mark P.

AU - Holcátová, Ivana

AU - Ahrens, Wolfgang

AU - Lagiou, Pagona

AU - Polesel, Jerry

AU - Simonato, Lorenzo

AU - Merletti, Franco

AU - Healy, Claire M.

AU - Kjaerheim, Kristina

AU - Conway, David I.

AU - Macfarlane, Tatiana V.

AU - Thomson, Peter

AU - Castellsagué, Xavier

AU - Znaor, Ariana

AU - Black, Amanda

AU - Huang, Wen Yi

AU - Krogh, Vittorio

AU - Trichopoulou, Antonia

AU - Bueno-De-Mesquita, H. B A S

AU - Clavel-Chapelon, Françoise

AU - Weiderpass, Elisabete

AU - Ekström, Johanna

AU - Riboli, Elio

AU - Tjønneland, Anne

AU - Sánchez, María José

AU - Travis, Ruth C.

AU - Hildesheim, Allan

AU - Pawlita, Michael

AU - Kreimer, Aimée R.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: The increasing incidence of oropharyngeal cancer in many developed countries has been attributed to human papillomavirus type 16 (HPV16) infections. Recently, HPV16 E6 serology has been identified as a promising early marker for oropharyngeal cancer. Therefore, characterization of HPV16 E6 seropositivity among individuals without cancer is warranted. Methods: A total of 4,666 controls were pooled from several studies of cancer and HPV seropositivity, all tested within the same laboratory. HPV16 E6 seropositive controls were classified as having (i) moderate [mean fluorescent intensity (MFI) ≥ 484 and

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Human papillomavirus 16 E6 antibodies in individuals without diagnosed cancer: A pooled analysis

Abstract

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