Human papillomavirus-32-positive extragenital bowenoid papulosis (BP) in a HIV patient with typical genital BP localization

Anna Marta Degener, Luigi Laino, Alessandra Pierangeli, Gianluca Accappaticcio, Daniele Innocenzi, Salvatore Pala

Research output: Contribution to journalArticle

Abstract

Objectives: Bowenoid papulosis (BP) is characterized by multiple maculopapular lesions of the genitalia; extragenital localization is rarely found. Human papillomavirus (HPV) type 16 has been found in most cases of BP, but the other HPV genotypes associated with BP had been poorly characterized. Goal: We describe an extragenital BP with concomitant genital involvement in an HIV-positive woman. Study: Several HPV gene-specific amplifications and sequencing were performed on DNA extracted from biopsy samples. Results: The presence of HPV-16 DNA in anogenital and HPV-32 DNA in lip lesions was demonstrated in the absence of any other HPV type and with no coinfection. Semiquantitative polymerase chain reaction analysis revealed that HPV-16 and -32 DNA sequences are in the episomal state. Conclusions: This is the first report of BP associated with HPV-32 (the causative agent of a benign hyperplasia) and a rare case of BP associated with 2 HPV types in the same patient. The immune depression could have modified the normal benign progression of the extragenital lesions.

Original languageEnglish
Pages (from-to)619-622
Number of pages4
JournalSexually Transmitted Diseases
Volume31
Issue number10
Publication statusPublished - Oct 2004

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ASJC Scopus subject areas

  • Dermatology
  • Microbiology (medical)
  • Public Health, Environmental and Occupational Health

Cite this

Degener, A. M., Laino, L., Pierangeli, A., Accappaticcio, G., Innocenzi, D., & Pala, S. (2004). Human papillomavirus-32-positive extragenital bowenoid papulosis (BP) in a HIV patient with typical genital BP localization. Sexually Transmitted Diseases, 31(10), 619-622.