Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study

Jan N. Bouwes Bavinck, Mariet C.W. Feltkamp, Adele C. Green, Marta Fiocco, Sylvie Euvrard, Catherine A. Harwood, Charlotte M. Proby, Luigi Naldi, Janouk C.D. Diphoorn, Anna Venturuzzo, Gianpaolo Tessari, Ingo Nindl, Francesca Sampogna, Damiano Abeni, Rachel E. Neale, Jelle J. Goeman, Koen D. Quint, Anne B. Halk, Carmen Sneek, Roel E. GendersMaurits N.C. de Koning, Wim G.V. Quint, Ulrike Wieland, Sönke Weissenborn, Tim Waterboer, Michael Pawlita, Herbert Pfister

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Organ transplant recipients (OTRs) have a 100-fold increased risk of cutaneous squamous cell carcinoma (cSCC). We prospectively evaluated the association between β genus human papillomaviruses (βPV) and keratinocyte carcinoma in OTRs. Two OTR cohorts without cSCC were assembled: cohort 1 was transplanted in 2003-2006 (n = 274) and cohort 2 was transplanted in 1986-2002 (n = 352). Participants were followed until death or cessation of follow-up in 2016. βPV infection was assessed in eyebrow hair by using polymerase chain reaction-based methods. βPV IgG seroresponses were determined with multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of βPV by using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HRs). OTRs with 5 or more different βPV types in eyebrow hair had 1.7 times the risk of cSCC vs OTRs with 0 to 4 different types (HR 1.7, 95% confidence interval 1.1-2.6). A similar risk was seen with high βPV loads (HR 1.8, 95% confidence interval 1.2-2.8). No significant associations were seen between serum antibodies and cSCC or between βPV and basal cell carcinoma. The diversity and load of βPV types in eyebrow hair are associated with cSCC risk in OTRs, providing evidence that βPV is associated with cSCC carcinogenesis and may present a target for future preventive strategies.

Original languageEnglish
JournalAmerican Journal of Transplantation
DOIs
Publication statusAccepted/In press - Jan 1 2017

Fingerprint

Squamous Cell Carcinoma
Cohort Studies
Prospective Studies
Skin
Eyebrows
Transplants
Hair
Confidence Intervals
Papillomavirus Infections
Basal Cell Carcinoma
Serology
Keratinocytes
Proportional Hazards Models
Transplant Recipients
Carcinogenesis
Immunoglobulin G
Carcinoma
Polymerase Chain Reaction
Antibodies
Incidence

Keywords

  • Cancer/malignancy/neoplasia: risk factors
  • Cancer/malignancy/neoplasia: skin - nonmelanoma
  • Clinical research/practice
  • Infection and infectious agents - viral
  • Infection and infectious agents - viral: papillomavirus
  • Organ transplantation in general

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Bouwes Bavinck, J. N., Feltkamp, M. C. W., Green, A. C., Fiocco, M., Euvrard, S., Harwood, C. A., ... Pfister, H. (Accepted/In press). Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study. American Journal of Transplantation. https://doi.org/10.1111/ajt.14537

Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma : A multicenter, prospective cohort study. / Bouwes Bavinck, Jan N.; Feltkamp, Mariet C.W.; Green, Adele C.; Fiocco, Marta; Euvrard, Sylvie; Harwood, Catherine A.; Proby, Charlotte M.; Naldi, Luigi; Diphoorn, Janouk C.D.; Venturuzzo, Anna; Tessari, Gianpaolo; Nindl, Ingo; Sampogna, Francesca; Abeni, Damiano; Neale, Rachel E.; Goeman, Jelle J.; Quint, Koen D.; Halk, Anne B.; Sneek, Carmen; Genders, Roel E.; de Koning, Maurits N.C.; Quint, Wim G.V.; Wieland, Ulrike; Weissenborn, Sönke; Waterboer, Tim; Pawlita, Michael; Pfister, Herbert.

In: American Journal of Transplantation, 01.01.2017.

Research output: Contribution to journalArticle

Bouwes Bavinck, JN, Feltkamp, MCW, Green, AC, Fiocco, M, Euvrard, S, Harwood, CA, Proby, CM, Naldi, L, Diphoorn, JCD, Venturuzzo, A, Tessari, G, Nindl, I, Sampogna, F, Abeni, D, Neale, RE, Goeman, JJ, Quint, KD, Halk, AB, Sneek, C, Genders, RE, de Koning, MNC, Quint, WGV, Wieland, U, Weissenborn, S, Waterboer, T, Pawlita, M & Pfister, H 2017, 'Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: A multicenter, prospective cohort study', American Journal of Transplantation. https://doi.org/10.1111/ajt.14537
Bouwes Bavinck, Jan N. ; Feltkamp, Mariet C.W. ; Green, Adele C. ; Fiocco, Marta ; Euvrard, Sylvie ; Harwood, Catherine A. ; Proby, Charlotte M. ; Naldi, Luigi ; Diphoorn, Janouk C.D. ; Venturuzzo, Anna ; Tessari, Gianpaolo ; Nindl, Ingo ; Sampogna, Francesca ; Abeni, Damiano ; Neale, Rachel E. ; Goeman, Jelle J. ; Quint, Koen D. ; Halk, Anne B. ; Sneek, Carmen ; Genders, Roel E. ; de Koning, Maurits N.C. ; Quint, Wim G.V. ; Wieland, Ulrike ; Weissenborn, Sönke ; Waterboer, Tim ; Pawlita, Michael ; Pfister, Herbert. / Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma : A multicenter, prospective cohort study. In: American Journal of Transplantation. 2017.
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AU - Bouwes Bavinck, Jan N.

AU - Feltkamp, Mariet C.W.

AU - Green, Adele C.

AU - Fiocco, Marta

AU - Euvrard, Sylvie

AU - Harwood, Catherine A.

AU - Proby, Charlotte M.

AU - Naldi, Luigi

AU - Diphoorn, Janouk C.D.

AU - Venturuzzo, Anna

AU - Tessari, Gianpaolo

AU - Nindl, Ingo

AU - Sampogna, Francesca

AU - Abeni, Damiano

AU - Neale, Rachel E.

AU - Goeman, Jelle J.

AU - Quint, Koen D.

AU - Halk, Anne B.

AU - Sneek, Carmen

AU - Genders, Roel E.

AU - de Koning, Maurits N.C.

AU - Quint, Wim G.V.

AU - Wieland, Ulrike

AU - Weissenborn, Sönke

AU - Waterboer, Tim

AU - Pawlita, Michael

AU - Pfister, Herbert

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