Infecção cervical por papilomavírus humano: Genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero

Translated title of the contribution: Human papillomavirus cervical infection: Viral genotyping and risk factors for high-grade squamous intraepithelial lesion and cervix cancer

Vilma Guimarães de Mendonça, Maria José Bezerra Guimarães, José Luiz de Lima Filho, Carolina Guimarães de Mendona̧a, Danyelly Bruneska Gondim Martins, Sergio Crovella, Luiz Cláudio Arraes de Alencar

Research output: Contribution to journalArticle

Abstract

PURPOSE: to analyze the characteristics of viral infection and the risk factors for high-grade squamous intraepithelial lesion and cervical carcinoma in women with cervical HPV infection. METHODS: a case-control study was conducted on women with cervical HPV at a Gynecology reference service enrolled at the Public Health System, located in Recife, Northeastern Brazil. The groups of cases (72 women with high-grade squamous intraepithelial lesion or cervical cancer) and controls (176 women with normal Pap smear or benign alterations) were investigated for six viral genotypes (HPV 16, 18, 31, 33, 6, 11) in ecto- and endocervical material using MY09/MY11 primers. The independent variables were ranked in three levels of determination: distal (sociodemographic), intermediate (behavioral) and proximal (previous Pap smear). The homogeneity of proportions was tested (χ 2), unadjusted Odds Ratios (OR) were obtained and hierarchical logistic regression was applied to the final model, with adjustment of the effect of each variable to the outcome based on the variables in the same and previous levels of causality. RESULTS: the viral genotype of cervical infection was identified in 76.6% of the 248 women participating in the study. High-risk HPV genotypes (83.4% of cases and 67.1% of controls) were predominant, especially HPV 16 and 31. The distal risk factors identified were: living in a rural area (OR=2.71, 95%CI: 1.18-6.23), less than three years of study (OR=3.97, 95%CI: 2.09-7.54) and family income below two minimum wages (OR=3.30, 95%CI: 1.04-10.51); intermediate: four or more pregnancies (OR=2.00, 95%CI: 1.06-3.76).

Translated title of the contributionHuman papillomavirus cervical infection: Viral genotyping and risk factors for high-grade squamous intraepithelial lesion and cervix cancer
Original languagePortuguese
Pages (from-to)476-485
Number of pages10
JournalRevista Brasileira de Ginecologia e Obstetricia
Volume32
Issue number10
Publication statusPublished - Oct 2010

Keywords

  • Disease progression
  • Genotype
  • Papillomavirus infections/epidemiology
  • Risk factors
  • Uterine neoplasms
  • Vaginal smears

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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  • Cite this

    de Mendonça, V. G., Guimarães, M. J. B., de Lima Filho, J. L., de Mendona̧a, C. G., Martins, D. B. G., Crovella, S., & de Alencar, L. C. A. (2010). Infecção cervical por papilomavírus humano: Genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero. Revista Brasileira de Ginecologia e Obstetricia, 32(10), 476-485.