Infecção cervical por papilomavírus humano: Genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero

Translated title of the contribution: Human papillomavirus cervical infection: Viral genotyping and risk factors for high-grade squamous intraepithelial lesion and cervix cancer

Vilma Guimarães de Mendonça, Maria José Bezerra Guimarães, José Luiz de Lima Filho, Carolina Guimarães de Mendona̧a, Danyelly Bruneska Gondim Martins, Sergio Crovella, Luiz Cláudio Arraes de Alencar

Research output: Contribution to journalArticle

Abstract

PURPOSE: to analyze the characteristics of viral infection and the risk factors for high-grade squamous intraepithelial lesion and cervical carcinoma in women with cervical HPV infection. METHODS: a case-control study was conducted on women with cervical HPV at a Gynecology reference service enrolled at the Public Health System, located in Recife, Northeastern Brazil. The groups of cases (72 women with high-grade squamous intraepithelial lesion or cervical cancer) and controls (176 women with normal Pap smear or benign alterations) were investigated for six viral genotypes (HPV 16, 18, 31, 33, 6, 11) in ecto- and endocervical material using MY09/MY11 primers. The independent variables were ranked in three levels of determination: distal (sociodemographic), intermediate (behavioral) and proximal (previous Pap smear). The homogeneity of proportions was tested (χ 2), unadjusted Odds Ratios (OR) were obtained and hierarchical logistic regression was applied to the final model, with adjustment of the effect of each variable to the outcome based on the variables in the same and previous levels of causality. RESULTS: the viral genotype of cervical infection was identified in 76.6% of the 248 women participating in the study. High-risk HPV genotypes (83.4% of cases and 67.1% of controls) were predominant, especially HPV 16 and 31. The distal risk factors identified were: living in a rural area (OR=2.71, 95%CI: 1.18-6.23), less than three years of study (OR=3.97, 95%CI: 2.09-7.54) and family income below two minimum wages (OR=3.30, 95%CI: 1.04-10.51); intermediate: four or more pregnancies (OR=2.00, 95%CI: 1.06-3.76).

Original languagePortuguese
Pages (from-to)476-485
Number of pages10
JournalRevista Brasileira de Ginecologia e Obstetricia
Volume32
Issue number10
Publication statusPublished - Oct 2010

Fingerprint

Papillomavirus Infections
Uterine Cervical Neoplasms
Odds Ratio
Papanicolaou Test
Human papillomavirus 16
Genotype
Human papillomavirus 31
Social Adjustment
Human papillomavirus 18
Salaries and Fringe Benefits
Virus Diseases
Infection
Gynecology
Causality
Brazil
Case-Control Studies
Public Health
Logistic Models
Squamous Intraepithelial Lesions of the Cervix
Carcinoma

Keywords

  • Disease progression
  • Genotype
  • Papillomavirus infections/epidemiology
  • Risk factors
  • Uterine neoplasms
  • Vaginal smears

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

de Mendonça, V. G., Guimarães, M. J. B., de Lima Filho, J. L., de Mendona̧a, C. G., Martins, D. B. G., Crovella, S., & de Alencar, L. C. A. (2010). Infecção cervical por papilomavírus humano: Genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero. Revista Brasileira de Ginecologia e Obstetricia, 32(10), 476-485.

Infecção cervical por papilomavírus humano : Genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero. / de Mendonça, Vilma Guimarães; Guimarães, Maria José Bezerra; de Lima Filho, José Luiz; de Mendona̧a, Carolina Guimarães; Martins, Danyelly Bruneska Gondim; Crovella, Sergio; de Alencar, Luiz Cláudio Arraes.

In: Revista Brasileira de Ginecologia e Obstetricia, Vol. 32, No. 10, 10.2010, p. 476-485.

Research output: Contribution to journalArticle

de Mendonça, VG, Guimarães, MJB, de Lima Filho, JL, de Mendona̧a, CG, Martins, DBG, Crovella, S & de Alencar, LCA 2010, 'Infecção cervical por papilomavírus humano: Genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero', Revista Brasileira de Ginecologia e Obstetricia, vol. 32, no. 10, pp. 476-485.
de Mendonça, Vilma Guimarães ; Guimarães, Maria José Bezerra ; de Lima Filho, José Luiz ; de Mendona̧a, Carolina Guimarães ; Martins, Danyelly Bruneska Gondim ; Crovella, Sergio ; de Alencar, Luiz Cláudio Arraes. / Infecção cervical por papilomavírus humano : Genotipagem viral e fatores de risco para lesão intraepitelial de alto grau e câncer de colo do útero. In: Revista Brasileira de Ginecologia e Obstetricia. 2010 ; Vol. 32, No. 10. pp. 476-485.
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abstract = "PURPOSE: to analyze the characteristics of viral infection and the risk factors for high-grade squamous intraepithelial lesion and cervical carcinoma in women with cervical HPV infection. METHODS: a case-control study was conducted on women with cervical HPV at a Gynecology reference service enrolled at the Public Health System, located in Recife, Northeastern Brazil. The groups of cases (72 women with high-grade squamous intraepithelial lesion or cervical cancer) and controls (176 women with normal Pap smear or benign alterations) were investigated for six viral genotypes (HPV 16, 18, 31, 33, 6, 11) in ecto- and endocervical material using MY09/MY11 primers. The independent variables were ranked in three levels of determination: distal (sociodemographic), intermediate (behavioral) and proximal (previous Pap smear). The homogeneity of proportions was tested (χ 2), unadjusted Odds Ratios (OR) were obtained and hierarchical logistic regression was applied to the final model, with adjustment of the effect of each variable to the outcome based on the variables in the same and previous levels of causality. RESULTS: the viral genotype of cervical infection was identified in 76.6{\%} of the 248 women participating in the study. High-risk HPV genotypes (83.4{\%} of cases and 67.1{\%} of controls) were predominant, especially HPV 16 and 31. The distal risk factors identified were: living in a rural area (OR=2.71, 95{\%}CI: 1.18-6.23), less than three years of study (OR=3.97, 95{\%}CI: 2.09-7.54) and family income below two minimum wages (OR=3.30, 95{\%}CI: 1.04-10.51); intermediate: four or more pregnancies (OR=2.00, 95{\%}CI: 1.06-3.76).",
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