Human papillomavirus in breast cancer

Anna Di Lonardo, Aldo Venuti, Maria Luisa Marcante

Research output: Contribution to journalArticlepeer-review

Abstract

Histological sections from paraffin-embedded breast carcinoma and axillary lymph nodes were examined for the presence of human papillomaviruses by two different techniques: the polymerase chain reaction (PCR) and the in situ hybridization with biotin-labelled probes. By PCR we detected HPV 16 DNA sequences in 29.4% of breast tumours and in some metastatic lymph nodes, though we were unable to identify any HPV DNA sequences by in situ hybridization. These results suggest that HPV's could play a role in the genesis of breast neoplasia.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalBreast Cancer Research and Treatment
Volume21
Issue number2
DOIs
Publication statusPublished - Jun 1992

Keywords

  • breast cancer
  • HPV
  • in situ hybridization
  • PCR

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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