Human papillomavirus in head and neck carcinomas: Prevalence, physical status and relationship with clinical/pathological parameters

Gianna Badaracco, Aldo Venuti, Roberto Morello, Antonio Muller, Maria Luisa Marcante

Research output: Contribution to journalArticle

Abstract

The association of human papillomavirus (HPV) infection to head and neck squamous cell carcinomas was evaluated in 66 patients affected by tumours of the oral cavity (n = 38), the tonsil (n = 4), the pharynx (n = 2), and the larynx (n = 22). HPV DNA was detected by PCR-based assays, recognizing late and early genes. Twenty-four cases were HPV infected (36.4%), mostly by high and/or intermediate risk types. HPV 16 was integrated in 7/12 positive tumours without site-specificity. HPV infection was not related to age, gender, tumour stage, differentiation grade, and use of alcohol and/or tobacco. The findings indicate that HPV infection may be related to a proportion of head and neck carcinomas but its association is not as clear as that found in cervical cancer.

Original languageEnglish
Pages (from-to)1301-1305
Number of pages5
JournalAnticancer Research
Volume20
Issue number2 B
Publication statusPublished - 2000

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Keywords

  • Head and neck cancer
  • HPV physical state
  • HPV prevalence
  • HPV typing
  • Risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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