TY - JOUR
T1 - Human papillomavirus in head and neck carcinomas
T2 - Prevalence, physical status and relationship with clinical/pathological parameters
AU - Badaracco, Gianna
AU - Venuti, Aldo
AU - Morello, Roberto
AU - Muller, Antonio
AU - Marcante, Maria Luisa
PY - 2000
Y1 - 2000
N2 - The association of human papillomavirus (HPV) infection to head and neck squamous cell carcinomas was evaluated in 66 patients affected by tumours of the oral cavity (n = 38), the tonsil (n = 4), the pharynx (n = 2), and the larynx (n = 22). HPV DNA was detected by PCR-based assays, recognizing late and early genes. Twenty-four cases were HPV infected (36.4%), mostly by high and/or intermediate risk types. HPV 16 was integrated in 7/12 positive tumours without site-specificity. HPV infection was not related to age, gender, tumour stage, differentiation grade, and use of alcohol and/or tobacco. The findings indicate that HPV infection may be related to a proportion of head and neck carcinomas but its association is not as clear as that found in cervical cancer.
AB - The association of human papillomavirus (HPV) infection to head and neck squamous cell carcinomas was evaluated in 66 patients affected by tumours of the oral cavity (n = 38), the tonsil (n = 4), the pharynx (n = 2), and the larynx (n = 22). HPV DNA was detected by PCR-based assays, recognizing late and early genes. Twenty-four cases were HPV infected (36.4%), mostly by high and/or intermediate risk types. HPV 16 was integrated in 7/12 positive tumours without site-specificity. HPV infection was not related to age, gender, tumour stage, differentiation grade, and use of alcohol and/or tobacco. The findings indicate that HPV infection may be related to a proportion of head and neck carcinomas but its association is not as clear as that found in cervical cancer.
KW - Head and neck cancer
KW - HPV physical state
KW - HPV prevalence
KW - HPV typing
KW - Risk factors
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M3 - Article
C2 - 10810439
AN - SCOPUS:0034011859
VL - 20
SP - 1301
EP - 1305
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 2 B
ER -