Human papillomavirus infection and associated cervical disease in human immunodeficiency virus-infected women: Effect of highly active antiretroviral therapy

F. B. Lillo, D. Ferrari, F. Veglia, M. Origoni, M. A. Grasso, S. Lodini, E. Mastrorilli, G. Taccagni, A. Lazzarin, C. Uberti-Foppa

Research output: Contribution to journalArticle

Abstract

To determine the effect of highly active antiretroviral therapy (HAART) on high-risk human papillomavirus (HR-HPV) infections and related cervical lesions, the virologic and cytologic markers of HPV infection were prospectively studied in 163 human immunodeficiency virus (HIV)-infected women, including 27 untreated, 62 treated with reverse transcriptase inhibitors, and 74 treated with HAART. A high prevalence of both infections with HR-HPV types (68%) and squamous intraepithelial lesions (SILs; low grade, 20.2%; high grade, 6.2%) was observed. The risks of infection and disease were inversely correlated with CD4 cell counts (P = .015 and P = .022, respectively). During the observation period (mean, 15.4 months; range, 6-24 months), CD4 cell counts increased significantly only in subjects receiving HAART (P <.001). Persistence of HR-HPV infection and progression of SILs were comparable in the 3 groups. These results indicate that, even in the era of HAART, HIV-infected women should be monitored carefully for the emergence of high-grade SILs and cervical cancer.

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalJournal of Infectious Diseases
Volume184
Issue number5
DOIs
Publication statusPublished - Sep 1 2001

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Papillomavirus Infections
Highly Active Antiretroviral Therapy
HIV
CD4 Lymphocyte Count
Infection
Reverse Transcriptase Inhibitors
Uterine Cervical Neoplasms
Observation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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Human papillomavirus infection and associated cervical disease in human immunodeficiency virus-infected women : Effect of highly active antiretroviral therapy. / Lillo, F. B.; Ferrari, D.; Veglia, F.; Origoni, M.; Grasso, M. A.; Lodini, S.; Mastrorilli, E.; Taccagni, G.; Lazzarin, A.; Uberti-Foppa, C.

In: Journal of Infectious Diseases, Vol. 184, No. 5, 01.09.2001, p. 547-551.

Research output: Contribution to journalArticle

Lillo, F. B. ; Ferrari, D. ; Veglia, F. ; Origoni, M. ; Grasso, M. A. ; Lodini, S. ; Mastrorilli, E. ; Taccagni, G. ; Lazzarin, A. ; Uberti-Foppa, C. / Human papillomavirus infection and associated cervical disease in human immunodeficiency virus-infected women : Effect of highly active antiretroviral therapy. In: Journal of Infectious Diseases. 2001 ; Vol. 184, No. 5. pp. 547-551.
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