Human papillomavirus infection and associated cervical disease in human immunodeficiency virus-infected women: Effect of highly active antiretroviral therapy

F. B. Lillo, D. Ferrari, F. Veglia, M. Origoni, M. A. Grasso, S. Lodini, E. Mastrorilli, G. Taccagni, A. Lazzarin, C. Uberti-Foppa

Research output: Contribution to journalArticle

Abstract

To determine the effect of highly active antiretroviral therapy (HAART) on high-risk human papillomavirus (HR-HPV) infections and related cervical lesions, the virologic and cytologic markers of HPV infection were prospectively studied in 163 human immunodeficiency virus (HIV)-infected women, including 27 untreated, 62 treated with reverse transcriptase inhibitors, and 74 treated with HAART. A high prevalence of both infections with HR-HPV types (68%) and squamous intraepithelial lesions (SILs; low grade, 20.2%; high grade, 6.2%) was observed. The risks of infection and disease were inversely correlated with CD4 cell counts (P = .015 and P = .022, respectively). During the observation period (mean, 15.4 months; range, 6-24 months), CD4 cell counts increased significantly only in subjects receiving HAART (P <.001). Persistence of HR-HPV infection and progression of SILs were comparable in the 3 groups. These results indicate that, even in the era of HAART, HIV-infected women should be monitored carefully for the emergence of high-grade SILs and cervical cancer.

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalJournal of Infectious Diseases
Volume184
Issue number5
DOIs
Publication statusPublished - Sep 1 2001

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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