Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma: A case series from 2010 to 2014

Maria Gabriella Donà, Giuseppe Spriano, Barbara Pichi, Francesca Rollo, Valentina Laquintana, Renato Covello, Raul Pellini, Massimo Giuliani, Edoardo Pescarmona, Maria Benevolo

Research output: Contribution to journalArticle

Abstract

Aim: Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinomas (OPSCC) show better prognosis and response to therapy. We evaluated HPV-DNA prevalence, p16 overexpression and HPV-attributable fraction in recent consecutive OPSCCs. Materials & methods: 140 OPSCCs were analyzed for HPV-DNA using the INNO-LiPA assay and p16 overexpression using CINtec® Histology kit. Results: HPV-DNA prevalence was 40.7%, and was significantly higher in basaloid and nonkeratinizing SCCs, but similar in tonsillar and base of tongue SCCs. Moreover, 98.0% of the HPV-positive OPSCCs overexpressed p16, compared with 12.3% of the HPV-negative cases (p <0.0001). Based on HPV-DNA and p16 double positivity, 39.8% of the cases were HPV related. Conclusion: The high estimate of the HPV-attributable fraction suggests that a substantial proportion of OPSCC patients may be managed less intensively.

Original languageEnglish
Pages (from-to)1283-1291
Number of pages9
JournalFuture Microbiology
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

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Papillomavirus Infections
Squamous Cell Carcinoma
DNA
Tongue
Histology

Keywords

  • head and neck neoplasms
  • human papillomavirus
  • oropharyngeal neoplasms
  • p16INK4 protein
  • prevalence

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma : A case series from 2010 to 2014. / Donà, Maria Gabriella; Spriano, Giuseppe; Pichi, Barbara; Rollo, Francesca; Laquintana, Valentina; Covello, Renato; Pellini, Raul; Giuliani, Massimo; Pescarmona, Edoardo; Benevolo, Maria.

In: Future Microbiology, Vol. 10, No. 8, 01.08.2015, p. 1283-1291.

Research output: Contribution to journalArticle

Donà, MG, Spriano, G, Pichi, B, Rollo, F, Laquintana, V, Covello, R, Pellini, R, Giuliani, M, Pescarmona, E & Benevolo, M 2015, 'Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma: A case series from 2010 to 2014', Future Microbiology, vol. 10, no. 8, pp. 1283-1291. https://doi.org/10.2217/FMB.15.55
Donà, Maria Gabriella ; Spriano, Giuseppe ; Pichi, Barbara ; Rollo, Francesca ; Laquintana, Valentina ; Covello, Renato ; Pellini, Raul ; Giuliani, Massimo ; Pescarmona, Edoardo ; Benevolo, Maria. / Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma : A case series from 2010 to 2014. In: Future Microbiology. 2015 ; Vol. 10, No. 8. pp. 1283-1291.
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