Human papillomavirus infection is not involved in esophageal verrucous carcinoma

Rocco Cappellesso, Irene Coati, Luisa Barzon, Elektra Peta, Giulia Masi, Marco Scarpa, Cristiano Lanza, Mauro Michelotto, Alberto Ruol, Sonia Cesaro, Carlo Castoro, Giorgio Palù, Gerard J Nuovo, Matteo Fassan, Massimo Rugge

Research output: Contribution to journalArticle

Abstract

Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Using three different molecular test methods, not one of these cases of VCE featured HPV infection. The only case with synchronous nodal metastasis was characterized by a TP53 missense point mutation in association with high EGFR and low E-cadherin expression levels. In conclusion, HPV infection is probably not involved VCE, while TP53 gene mutation, EGFR overexpression, and E-cadherin loss might fuel the tumor's proliferation and lend it a metastatic potential.

Original languageEnglish
JournalHuman Pathology
DOIs
Publication statusE-pub ahead of print - Nov 10 2018

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Verrucous Carcinoma
Papillomavirus Infections
Esophagus
Cadherins
p53 Genes
Squamous Cell Neoplasms
Cyclin D1
Missense Mutation
Natural History
Point Mutation
Exons
Neoplasms
Neoplasm Metastasis
Phenotype
Mutation

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Human papillomavirus infection is not involved in esophageal verrucous carcinoma. / Cappellesso, Rocco; Coati, Irene; Barzon, Luisa; Peta, Elektra; Masi, Giulia; Scarpa, Marco; Lanza, Cristiano; Michelotto, Mauro; Ruol, Alberto; Cesaro, Sonia; Castoro, Carlo; Palù, Giorgio; Nuovo, Gerard J; Fassan, Matteo; Rugge, Massimo.

In: Human Pathology, 10.11.2018.

Research output: Contribution to journalArticle

Cappellesso, R, Coati, I, Barzon, L, Peta, E, Masi, G, Scarpa, M, Lanza, C, Michelotto, M, Ruol, A, Cesaro, S, Castoro, C, Palù, G, Nuovo, GJ, Fassan, M & Rugge, M 2018, 'Human papillomavirus infection is not involved in esophageal verrucous carcinoma', Human Pathology. https://doi.org/10.1016/j.humpath.2018.10.024
Cappellesso, Rocco ; Coati, Irene ; Barzon, Luisa ; Peta, Elektra ; Masi, Giulia ; Scarpa, Marco ; Lanza, Cristiano ; Michelotto, Mauro ; Ruol, Alberto ; Cesaro, Sonia ; Castoro, Carlo ; Palù, Giorgio ; Nuovo, Gerard J ; Fassan, Matteo ; Rugge, Massimo. / Human papillomavirus infection is not involved in esophageal verrucous carcinoma. In: Human Pathology. 2018.
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abstract = "Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Using three different molecular test methods, not one of these cases of VCE featured HPV infection. The only case with synchronous nodal metastasis was characterized by a TP53 missense point mutation in association with high EGFR and low E-cadherin expression levels. In conclusion, HPV infection is probably not involved VCE, while TP53 gene mutation, EGFR overexpression, and E-cadherin loss might fuel the tumor's proliferation and lend it a metastatic potential.",
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AU - Cappellesso, Rocco

AU - Coati, Irene

AU - Barzon, Luisa

AU - Peta, Elektra

AU - Masi, Giulia

AU - Scarpa, Marco

AU - Lanza, Cristiano

AU - Michelotto, Mauro

AU - Ruol, Alberto

AU - Cesaro, Sonia

AU - Castoro, Carlo

AU - Palù, Giorgio

AU - Nuovo, Gerard J

AU - Fassan, Matteo

AU - Rugge, Massimo

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AB - Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Using three different molecular test methods, not one of these cases of VCE featured HPV infection. The only case with synchronous nodal metastasis was characterized by a TP53 missense point mutation in association with high EGFR and low E-cadherin expression levels. In conclusion, HPV infection is probably not involved VCE, while TP53 gene mutation, EGFR overexpression, and E-cadherin loss might fuel the tumor's proliferation and lend it a metastatic potential.

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