Abstract
Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Using three different molecular test methods, not one of these cases of VCE featured HPV infection. The only case with synchronous nodal metastasis was characterized by a TP53 missense point mutation in association with high EGFR and low E-cadherin expression levels. In conclusion, HPV infection is probably not involved VCE, while TP53 gene mutation, EGFR overexpression, and E-cadherin loss might fuel the tumor's proliferation and lend it a metastatic potential.
| Original language | English |
|---|---|
| Journal | Human Pathology |
| DOIs | |
| Publication status | E-pub ahead of print - Nov 10 2018 |
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Human papillomavirus infection is not involved in esophageal verrucous carcinoma. / Cappellesso, Rocco; Coati, Irene; Barzon, Luisa; Peta, Elektra; Masi, Giulia; Scarpa, Marco; Lanza, Cristiano; Michelotto, Mauro; Ruol, Alberto; Cesaro, Sonia; Castoro, Carlo; Palù, Giorgio; Nuovo, Gerard J; Fassan, Matteo; Rugge, Massimo.
In: Human Pathology, 10.11.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human papillomavirus infection is not involved in esophageal verrucous carcinoma
AU - Cappellesso, Rocco
AU - Coati, Irene
AU - Barzon, Luisa
AU - Peta, Elektra
AU - Masi, Giulia
AU - Scarpa, Marco
AU - Lanza, Cristiano
AU - Michelotto, Mauro
AU - Ruol, Alberto
AU - Cesaro, Sonia
AU - Castoro, Carlo
AU - Palù, Giorgio
AU - Nuovo, Gerard J
AU - Fassan, Matteo
AU - Rugge, Massimo
N1 - Copyright © 2018. Published by Elsevier Inc.
PY - 2018/11/10
Y1 - 2018/11/10
N2 - Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Using three different molecular test methods, not one of these cases of VCE featured HPV infection. The only case with synchronous nodal metastasis was characterized by a TP53 missense point mutation in association with high EGFR and low E-cadherin expression levels. In conclusion, HPV infection is probably not involved VCE, while TP53 gene mutation, EGFR overexpression, and E-cadherin loss might fuel the tumor's proliferation and lend it a metastatic potential.
AB - Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Using three different molecular test methods, not one of these cases of VCE featured HPV infection. The only case with synchronous nodal metastasis was characterized by a TP53 missense point mutation in association with high EGFR and low E-cadherin expression levels. In conclusion, HPV infection is probably not involved VCE, while TP53 gene mutation, EGFR overexpression, and E-cadherin loss might fuel the tumor's proliferation and lend it a metastatic potential.
U2 - 10.1016/j.humpath.2018.10.024
DO - 10.1016/j.humpath.2018.10.024
M3 - Article
C2 - 30423307
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
ER -