TY - JOUR
T1 - Human papillomavirus prevalence is high in oral samples of patients with tonsillar and base of tongue cancer
AU - Nordfors, Cecilia
AU - Vlastos, Andrea
AU - Du, Juan
AU - Ährlund-Richter, Andreas
AU - Tertipis, Nikolaos
AU - Grün, Nathalie
AU - Romanitan, Mircea
AU - Haeggblom, Linnea
AU - Roosaar, Ann
AU - Dahllöf, Göran
AU - Donà, Maria Gabriella
AU - Benevolo, Maria
AU - Ramqvist, Torbjörn
AU - Munck-Wikland, Eva
AU - Dalianis, Tina
PY - 2014
Y1 - 2014
N2 - Material and methods Presence of HPV DNA was analyzed in mouthwash and tonsillar swab samples, if indicative of HPV-positive tonsillar or base of tongue cancer in 76 patients, with suspected head neck cancer, undergoing diagnostic endoscopy at Karolinska University Hospital. The diagnosis and tumor HPV status was later obtained from patients' records. As controls, 37 tumor-free dental visitors were included. Results Of the 76 patients, 22/29 (76%) and 16/18 (89%) had an HPV-positive tonsillar and base of tongue cancer respectively, with 18/22 (82%) and 8/16 (50%) respectively having tumor concordant HPV-type positive oral samples. Two other HPV-positive oral samples in the base of tongue cancer group did not correlate to the tumor HPV status. Among the remaining patients, 19 with other head neck cancer and 10 with benign conditions, 4/29 (14%) had HPV-positive oral samples. Consequently, of the HPV-positive oral samples, dominated by HPV16 and high signals, 27/32 (84%) were derived from 26 patients with concordant HPV-type positive tonsillar or base of tongue cancer and one patient with an unknown primary head and neck cancer. The other five HPV-positive oral samples, with mainly low signals were derived from two patients with non-concordant HPV-type positive tumor biopsies, two patients with HPV-negative tumor biopsies and a patient with a benign condition. Of the dental patients, 3/37 (8%) had HPV-positive tonsillar swabs with weak signals. Conclusion In patients with suspected head neck cancer, HPV-positive oral samples, especially HPV16 with high signals, could be indicative of HPV-positive tonsillar or base of tongue cancer.
AB - Material and methods Presence of HPV DNA was analyzed in mouthwash and tonsillar swab samples, if indicative of HPV-positive tonsillar or base of tongue cancer in 76 patients, with suspected head neck cancer, undergoing diagnostic endoscopy at Karolinska University Hospital. The diagnosis and tumor HPV status was later obtained from patients' records. As controls, 37 tumor-free dental visitors were included. Results Of the 76 patients, 22/29 (76%) and 16/18 (89%) had an HPV-positive tonsillar and base of tongue cancer respectively, with 18/22 (82%) and 8/16 (50%) respectively having tumor concordant HPV-type positive oral samples. Two other HPV-positive oral samples in the base of tongue cancer group did not correlate to the tumor HPV status. Among the remaining patients, 19 with other head neck cancer and 10 with benign conditions, 4/29 (14%) had HPV-positive oral samples. Consequently, of the HPV-positive oral samples, dominated by HPV16 and high signals, 27/32 (84%) were derived from 26 patients with concordant HPV-type positive tonsillar or base of tongue cancer and one patient with an unknown primary head and neck cancer. The other five HPV-positive oral samples, with mainly low signals were derived from two patients with non-concordant HPV-type positive tumor biopsies, two patients with HPV-negative tumor biopsies and a patient with a benign condition. Of the dental patients, 3/37 (8%) had HPV-positive tonsillar swabs with weak signals. Conclusion In patients with suspected head neck cancer, HPV-positive oral samples, especially HPV16 with high signals, could be indicative of HPV-positive tonsillar or base of tongue cancer.
KW - Human papillomavirus (HPV)
KW - Mouthwash samples
KW - Oral HPV infection
KW - Oropharyngeal squamous cell carcinoma
KW - Tonsillar cancer base of tongue cancer
KW - Tonsillar swabs
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U2 - 10.1016/j.oraloncology.2014.02.012
DO - 10.1016/j.oraloncology.2014.02.012
M3 - Article
C2 - 24613649
AN - SCOPUS:84898803843
VL - 50
SP - 491
EP - 497
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 5
ER -